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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2005 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2005 Volume 14 Issue 2

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Article

Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities

  • Authors:
    • Tomonori Harada
    • Masaya Nagasu
    • Isao Tsuboi
    • Morimichi Koshinaga
    • Hitoshi Kanno
    • Shin Aizawa

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, Nihon University School of Medicine, 30-1 Ohyaguchi-kami-machi, Itabashi-ku, Tokyo 173-8610, Japan
  • Pages: 501-505
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/or.14.2.501
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Abstract

A novel supramolecular oligomer, cyclic polylactate (CPL) that was originally discovered in the culture medium of HeLa-S tumor cells, reportedly inhibits the growth of FM3A ascites tumor cells by inhibiting enzymes involved in the glycolytic pathway. We synthesized CPL containing 3- to 13-mers by prolonged heating and rapidly mixing a carbohydrate compound of the L-lactic acid monomer (C3H6O3) under decreased pressure, and studied its effects on the growth of the cloned leukemic cell, TF-1. CPL inhibited the growth of TF-1 cells and induced 7A6 antigen, which is expressed by cells undergoing apoptosis, on the surface of TF-1 cells. In addition, caspase 3, 8 and 9 activities of TF-1 cells were increased after exposure to CPL, indicating that CPL induces apoptotic changes in TF-1. Among the 6 glycolytic enzymes examined in this study, the activities of PFK and HK, induced by CPL, decreased. Interestingly, CPL was detected in conditioned medium of the stromal cell line, LS801, obtained from human bone marrow. This conditioned medium inhibited the growth of TF-1 cells, and induced the expression of 7A6 antigen. These findings suggest that CPL will be a useful chemotherapeutic agent against leukemia.

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Copy and paste a formatted citation
Spandidos Publications style
Harada T, Nagasu M, Tsuboi I, Koshinaga M, Kanno H and Aizawa S: Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities. Oncol Rep 14: 501-505, 2005.
APA
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., & Aizawa, S. (2005). Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities. Oncology Reports, 14, 501-505. https://doi.org/10.3892/or.14.2.501
MLA
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., Aizawa, S."Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities". Oncology Reports 14.2 (2005): 501-505.
Chicago
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., Aizawa, S."Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities". Oncology Reports 14, no. 2 (2005): 501-505. https://doi.org/10.3892/or.14.2.501
Copy and paste a formatted citation
x
Spandidos Publications style
Harada T, Nagasu M, Tsuboi I, Koshinaga M, Kanno H and Aizawa S: Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities. Oncol Rep 14: 501-505, 2005.
APA
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., & Aizawa, S. (2005). Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities. Oncology Reports, 14, 501-505. https://doi.org/10.3892/or.14.2.501
MLA
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., Aizawa, S."Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities". Oncology Reports 14.2 (2005): 501-505.
Chicago
Harada, T., Nagasu, M., Tsuboi, I., Koshinaga, M., Kanno, H., Aizawa, S."Cyclic polylactate inhibited growth of cloned leukemic cells through reducing glycolytic enzyme activities". Oncology Reports 14, no. 2 (2005): 501-505. https://doi.org/10.3892/or.14.2.501
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