Clinical usefulness of serum and immunohistochemical markers in patients with stage Ia and Ic ovarian cancer

Muramatsu,Toshinari; Mukai,Masaya; Sato,Shinkichi; Tajima,Takayuki; Nagase,Eri; Ikeda,Masae; Goya,Ken-ichi; Shida,Masako; Hirasawa,Takeshi; Murakami,Masaru; Shinozuka,Takao

doi:10.3892/or.14.4.861

October 2005 Volume 14 Issue 4

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October 2005 Volume 14 Issue 4

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Article

Clinical usefulness of serum and immunohistochemical markers in patients with stage Ia and Ic ovarian cancer

Authors:
- Toshinari Muramatsu
- Masaya Mukai
- Shinkichi Sato
- Takayuki Tajima
- Eri Nagase
- Masae Ikeda
- Ken-ichi Goya
- Masako Shida
- Takeshi Hirasawa
- Masaru Murakami
- Takao Shinozuka
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa 259-1143, Japan. mura-to@is.icc.u-tokai.ac.jp
Pages: 861-865
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Published online on: October 1, 2005

https://doi.org/10.3892/or.14.4.861
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Abstract

We compared the preoperative serum tumor marker values and diameters of ovarian tumors between 14 stage Ia ovarian cancer patients with a good prognosis and 14 stage Ic patients with a poor prognosis. The aim was to examine the usability of tumor markers and diameter of ovarian tumors for prognostic diagnosis of clinically advanced phases. In occult neoplastic cells (ONCs), a tumor marker indicative of recurrence and metastasis, the cytokeratin-positive cells in lymph node biopsies, were also compared. In a preoperative comparison of serum tumor markers, CA125 levels in stage Ia and Ic patients were 47.1±15.9 (median, 31.9 U/ml) and 370.6±146.2 U/ml (median, 135.6 U/ml), respectively (p=0.0457), and CA19-9 levels were 25.5±5.5 (median, 20.4 U/ml) and 564.5±192.4 U/ml (median, 248.0 U/ml), respectively (p=0.0131). In a comparison of tumor diameters during surgery, diameters of stage Ia and Ic patients were 117.3±11.4 (median, 100.0 mm) and 182.0±29.2 mm (median, 145.0 mm), respectively (p=0.0457). ONCs were not detected in any stage Ia patients, but detected in 3 (30%) stage Ic patients. In conclusion, clinical progression was evaluated using CA125 and CA19-9 serum markers and tumor diameters in stage Ia and Ic patients, and demonstrated significant differences between stage. ONCs were only detected in the lymph nodes of stage Ic patients.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clinical usefulness of serum and immunohistochemical markers in patients with stage Ia and Ic ovarian cancer

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