Expression of HIF-1α and Glut-1 in human bladder cancer

  • Authors:
    • V. Palit
    • R. M. Phillips
    • R. Puri
    • T. Shah
    • M. C. Bibby
  • View Affiliations

  • Published online on: October 1, 2005     https://doi.org/10.3892/or.14.4.909
  • Pages: 909-913
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Abstract

HIF-1 is a heterodimer consisting of the HIF-1α and HIF-1β subunits, and HIF-1α is the unique oxygen regulated subunit that determines HIF-1 activity. HIF-1α upgrades many gene products which include the glucose transporter protein 1 (Glut-1). Immunohistochemical studies using a monoclonal antibody specific for HIF-1α indicate that the overexpression of HIF-1α occurs in the most common forms of human cancer, including bladder cancer. The expression of Glut-1 in human bladder cancer is associated with poor prognosis and a low survival rate. To our knowledge, this is the first study to compare the expression of both HIF-1α and Glut-1 with clinicopathological characteristics in superficial and invasive human bladder cancer (all invasive bladder cancer patients received radical radiotherapy). The Kaplan-Meier survival analysis curve shows a significant association of HIF-1α expression with recurrence and survival in superficial bladder cancer and shows a significant association of Glut-1 with survival in invasive bladder cancer [chi2 (4)=10.52; Pr >chi2 =0.0012].

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October 2005
Volume 14 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Palit V, Phillips RM, Puri R, Shah T and Bibby MC: Expression of HIF-1α and Glut-1 in human bladder cancer. Oncol Rep 14: 909-913, 2005
APA
Palit, V., Phillips, R.M., Puri, R., Shah, T., & Bibby, M.C. (2005). Expression of HIF-1α and Glut-1 in human bladder cancer. Oncology Reports, 14, 909-913. https://doi.org/10.3892/or.14.4.909
MLA
Palit, V., Phillips, R. M., Puri, R., Shah, T., Bibby, M. C."Expression of HIF-1α and Glut-1 in human bladder cancer". Oncology Reports 14.4 (2005): 909-913.
Chicago
Palit, V., Phillips, R. M., Puri, R., Shah, T., Bibby, M. C."Expression of HIF-1α and Glut-1 in human bladder cancer". Oncology Reports 14, no. 4 (2005): 909-913. https://doi.org/10.3892/or.14.4.909