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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2005 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma

  • Authors:
    • Hideoki Uryu
    • Yoshinao Oda
    • Hideki Shiratsuchi
    • Shinya Oda
    • Hidetaka Yamamoto
    • Shizuo Komune
    • Masazumi Tsuneyoshi

  • View Affiliations / Copyright

    Affiliations: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
  • Pages: 1133-1142
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/or.14.5.1133
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Abstract

Sinonasal carcinomas arise from the respiratory epithelium that lines the nasal and paranasal cavities, and are histologically composed of either squamous or cylindrical cell carcinoma. However, molecular analysis with the purpose of distinguishing sinonasal carcinomas from other head and neck squamous cell carcinomas (HNSCCs), which arise from squamous epithelium, has been limited. Moreover, a wide range of frequency of microsatellite instability (MSI) in HNSCC has been reported. Using high-resolution fluorescent microsatellite analysis (HFRMA), we studied microsatellite alterations in 34 patients with sinonasal carcinoma. As a control, 24 oral squamous cell carcinomas were used. MSI was detected in 14 patients with sinonasal carcinoma (41%), but not in any with oral squamous cell carcinoma (p=0.002). Furthermore, in sinonasal carcinoma, 11 out of 17 (65%) T1-T3 sinonasal carcinomas demonstrated MSI, whereas only 3 out of 15 (20%) T4 tumors demonstrated MSI. Immunohistochemically, sinonasal carcinoma showed a higher MIB-1-labeling index and more frequently showed cytokeratin 18 expression when compared with oral squamous cell carcinoma. These findings suggest that sinonasal carcinoma and HNSCC have quite different molecular backgrounds regarding carcinogenesis, and the role of MSI is relatively minor in cases of advanced sinonasal carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Uryu H, Oda Y, Shiratsuchi H, Oda S, Yamamoto H, Komune S and Tsuneyoshi M: Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. Oncol Rep 14: 1133-1142, 2005.
APA
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., & Tsuneyoshi, M. (2005). Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. Oncology Reports, 14, 1133-1142. https://doi.org/10.3892/or.14.5.1133
MLA
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., Tsuneyoshi, M."Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma". Oncology Reports 14.5 (2005): 1133-1142.
Chicago
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., Tsuneyoshi, M."Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma". Oncology Reports 14, no. 5 (2005): 1133-1142. https://doi.org/10.3892/or.14.5.1133
Copy and paste a formatted citation
x
Spandidos Publications style
Uryu H, Oda Y, Shiratsuchi H, Oda S, Yamamoto H, Komune S and Tsuneyoshi M: Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. Oncol Rep 14: 1133-1142, 2005.
APA
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., & Tsuneyoshi, M. (2005). Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma. Oncology Reports, 14, 1133-1142. https://doi.org/10.3892/or.14.5.1133
MLA
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., Tsuneyoshi, M."Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma". Oncology Reports 14.5 (2005): 1133-1142.
Chicago
Uryu, H., Oda, Y., Shiratsuchi, H., Oda, S., Yamamoto, H., Komune, S., Tsuneyoshi, M."Microsatellite instability and proliferating activity in sinonasal carcinoma: Molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma". Oncology Reports 14, no. 5 (2005): 1133-1142. https://doi.org/10.3892/or.14.5.1133
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