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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2005 Volume 14 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Development of an HT29 liver metastases model in nude rats

  • Authors:
    • Frédéric Marchal
    • N'guyen Tran
    • Sophie Marchal
    • Agnès Leroux
    • Christian Marchal
    • Lina Bolotine
    • François Guillemin
    • Jean Pierre Villemot

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Centre Alexis Vautrin, Av. de Bourgogne, 54511 Vandoeuvre-lès-Nancy, France
  • Pages: 1203-1207
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/or.14.5.1203
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Abstract

The liver is the most frequent and fatal site of distant spreading of colorectal cancer. Most liver metastases animal models involve nude mice and an injection of tumour cells through the spleen or portal vein, or orthotopic implantation of tumour cells in the colon wall. The aim of this study was to develop a reliable rat model of liver metastases with human colorectal HT29 cells. Seventy male athymic Rowett nude rats weighing 300±30 g were separated into three groups. The first group (n=20) consisted of untreated rats, rats in the second group (n=20) were immunosuppressed by cyclosporin A, and those in the third group (n=30) were irradiated the day before cell grafting. Tumour cells (2x107) were subcapsulary injected into the liver, and rats were sacrificed after 60 days. The livers were excised, and tumours were serially sectioned to determine size and volume, then fixed for histological studies. The take-rate was 55% in the first group, 35% in the second and 74% in the third group. The mean volume of tumours in the first group was 537±162 mm3, 613±232 mm3 in the second group and 2949±629 mm3 in the third group. In conclusion, subcapsular injection of the human colonic HT29 cancer cells into the liver of preoperatively irradiated nude rats is a reliable, reproducible and easily obtained model, which should be useful for preclinical studies.

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Copy and paste a formatted citation
Spandidos Publications style
Marchal F, Tran N, Marchal S, Leroux A, Marchal C, Bolotine L, Guillemin F and Villemot JP: Development of an HT29 liver metastases model in nude rats. Oncol Rep 14: 1203-1207, 2005.
APA
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L. ... Villemot, J.P. (2005). Development of an HT29 liver metastases model in nude rats. Oncology Reports, 14, 1203-1207. https://doi.org/10.3892/or.14.5.1203
MLA
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L., Guillemin, F., Villemot, J. P."Development of an HT29 liver metastases model in nude rats". Oncology Reports 14.5 (2005): 1203-1207.
Chicago
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L., Guillemin, F., Villemot, J. P."Development of an HT29 liver metastases model in nude rats". Oncology Reports 14, no. 5 (2005): 1203-1207. https://doi.org/10.3892/or.14.5.1203
Copy and paste a formatted citation
x
Spandidos Publications style
Marchal F, Tran N, Marchal S, Leroux A, Marchal C, Bolotine L, Guillemin F and Villemot JP: Development of an HT29 liver metastases model in nude rats. Oncol Rep 14: 1203-1207, 2005.
APA
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L. ... Villemot, J.P. (2005). Development of an HT29 liver metastases model in nude rats. Oncology Reports, 14, 1203-1207. https://doi.org/10.3892/or.14.5.1203
MLA
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L., Guillemin, F., Villemot, J. P."Development of an HT29 liver metastases model in nude rats". Oncology Reports 14.5 (2005): 1203-1207.
Chicago
Marchal, F., Tran, N., Marchal, S., Leroux, A., Marchal, C., Bolotine, L., Guillemin, F., Villemot, J. P."Development of an HT29 liver metastases model in nude rats". Oncology Reports 14, no. 5 (2005): 1203-1207. https://doi.org/10.3892/or.14.5.1203
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