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Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy

  • Authors:
    • Masataro Hayashi
    • Shigeto Kawauchi
    • Kazuhiro Ueda
    • Yoshikazu Kaneda
    • Atsunori Oga
    • Tomoko Furuya
    • Kimikazu Hamano
    • Kohsuke Sasaki

  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/or.14.6.1429
  • Pages: 1429-1435
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Abstract

To clarify the clinicopathological and biological significance of genomic alterations in pulmonary adenocarcinomas, we examined chromosomal DNA sequence copy number aberrations (DSCNAs) and DNA ploidy in 42 surgically resected specimens by comparative genomic hybridization (CGH) and laser scanning cytometry (LSC), respectively. The number of DSCNA did not affect the size of carcinoma or number of nodal metastasis. More than 60% of carcinomas showed a 1q21-23 gain or 13q21 loss. Gains of 9q22-33 and 10q26-qter and a loss of 15q14-qter were significantly associated with nodal metastasis (p<0.05). Of 42 pulmonary adenocarcinomas, 32 (76%) showed DNA aneuploidy. The number of DSCNAs in aneuploid carcinomas was larger than that in diploid carcinomas (p<0.01). Our results suggest that diploid and aneuploid types are cytogenetically different in pulmonary adenocarcinomas and aneuploid carcinomas are genetically more unstable and aggressive than diploid carcinomas.

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December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Hayashi M, Kawauchi S, Ueda K, Kaneda Y, Oga A, Furuya T, Hamano K and Sasaki K: Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy. Oncol Rep 14: 1429-1435, 2005
APA
Hayashi, M., Kawauchi, S., Ueda, K., Kaneda, Y., Oga, A., Furuya, T. ... Sasaki, K. (2005). Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy. Oncology Reports, 14, 1429-1435. https://doi.org/10.3892/or.14.6.1429
MLA
Hayashi, M., Kawauchi, S., Ueda, K., Kaneda, Y., Oga, A., Furuya, T., Hamano, K., Sasaki, K."Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy". Oncology Reports 14.6 (2005): 1429-1435.
Chicago
Hayashi, M., Kawauchi, S., Ueda, K., Kaneda, Y., Oga, A., Furuya, T., Hamano, K., Sasaki, K."Genomic alterations detected by comparative genomic hybridization in primary lung adenocarcinomas with special reference to the relationship with DNA ploidy". Oncology Reports 14, no. 6 (2005): 1429-1435. https://doi.org/10.3892/or.14.6.1429