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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome

  • Authors:
    • Minoru Nakase
    • Kenya Okumura
    • Takahiko Kamei
    • Shinnosuke Nakamura
    • Madoka Inui
    • Toshiro Tagawa

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan. nakase96@clin.medic.mie-u.ac.jp
  • Pages: 1487-1491
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1487
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Abstract

The transfection efficiency of cationic liposomes varies according to cell type, but the specific cellular characteristics that affect transfection efficiency have not yet been defined. We investigated whether the transfection efficiency of cationic liposomes correlates with cell proliferation activity or cell membrane potential in oral malignant melanoma (HMG) and oral osteosarcoma cell lines (HOSM-1 and HOSM-2). The cell membrane potential was assessed by uptake of a cationic probe. Three oral tumor cell lines were exposed to a cationic liposome complexed with a β-galactosidase expression plasmid, and β-galactosidase expression was compared. Cell proliferation was about 2-fold higher in HOSM-1 cells than in HMG cells. The cell membrane potential in HMG and HOSM-1 cells was comparable, while the membrane potential in HOSM-2 cells was 1.6-fold higher. β-galactosidase expression was measured by X-Gal staining in 7.0% of HMG, 17.0% of HOSM-1 and 11.5% of HOSM-2 cells. The present study demonstrates that gene therapy with cationic liposomes may be a promising new strategy for treatment of oral malignant melanoma and osteosarcoma. In addition, the transfection efficiency of cationic liposomes appears to be influenced by cell proliferation activity, but not cell membrane potential.

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Copy and paste a formatted citation
Spandidos Publications style
Nakase M, Okumura K, Kamei T, Nakamura S, Inui M and Tagawa T: The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome. Oncol Rep 14: 1487-1491, 2005.
APA
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., & Tagawa, T. (2005). The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome. Oncology Reports, 14, 1487-1491. https://doi.org/10.3892/or.14.6.1487
MLA
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., Tagawa, T."The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome". Oncology Reports 14.6 (2005): 1487-1491.
Chicago
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., Tagawa, T."The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome". Oncology Reports 14, no. 6 (2005): 1487-1491. https://doi.org/10.3892/or.14.6.1487
Copy and paste a formatted citation
x
Spandidos Publications style
Nakase M, Okumura K, Kamei T, Nakamura S, Inui M and Tagawa T: The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome. Oncol Rep 14: 1487-1491, 2005.
APA
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., & Tagawa, T. (2005). The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome. Oncology Reports, 14, 1487-1491. https://doi.org/10.3892/or.14.6.1487
MLA
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., Tagawa, T."The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome". Oncology Reports 14.6 (2005): 1487-1491.
Chicago
Nakase, M., Okumura, K., Kamei, T., Nakamura, S., Inui, M., Tagawa, T."The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome". Oncology Reports 14, no. 6 (2005): 1487-1491. https://doi.org/10.3892/or.14.6.1487
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