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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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December 2005 Volume 14 Issue 6

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Article

Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis

  • Authors:
    • Jin-Ting Zhang
    • Qing-Xing Li
    • Dawei Wang
    • Zhen-Long Zhu
    • Yan-Hong Yang
    • Dong-Sheng Cui
    • Ming-Wei Wang
    • Xiao-Feng Sun

  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, The First Hospital of Hebei Medical University, Shijiazhuang, China
  • Pages: 1519-1522
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1519
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Abstract

Particularly interesting new cysteine-histidine rich protein (PINCH), an adapter protein involved in integrin and growth factor signalling, is up-regulated in the stroma of colorectal, breast, prostate, lung and skin cancer. Strong stromal immunostaining for PINCH is an independent prognostic indicator for reduced survival in colorectal cancer, suggesting that PINCH is involved in the signalling that promotes tumour progression. Since no study on PINCH has been carried out in oral squamous cell carcinoma (OSCC), this study aimed to determine PINCH expression in OSCC and its clinicopathological significance. PINCH protein expression was examined by immunohistochemistry in 20 normal oral mucosa and in 57 OSCC specimens. The frequency of strong PINCH immunostaining was higher in tumour-associated stroma of OSCC (37%) as compared to normal oral mucosa (10%) (p=0.02). Strong PINCH stromal immunostaining predicted nodal metastasis: 19/26 (73%) OSCC cases with nodal metastasis had strong PINCH immunostaining compared to 9/31 (29%) cases without nodal metastasis (p=0.02). The PINCH expression in OSCC was more intense in stroma at the invasive edge than in intratumoural stroma. In conclusion, the up-regulation of PINCH protein in stroma may be involved in promoting invasion and metastasis in OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Li Q, Wang D, Zhu Z, Yang Y, Cui D, Wang M and Sun X: Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis. Oncol Rep 14: 1519-1522, 2005.
APA
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D. ... Sun, X. (2005). Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis. Oncology Reports, 14, 1519-1522. https://doi.org/10.3892/or.14.6.1519
MLA
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D., Wang, M., Sun, X."Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis". Oncology Reports 14.6 (2005): 1519-1522.
Chicago
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D., Wang, M., Sun, X."Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis". Oncology Reports 14, no. 6 (2005): 1519-1522. https://doi.org/10.3892/or.14.6.1519
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Li Q, Wang D, Zhu Z, Yang Y, Cui D, Wang M and Sun X: Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis. Oncol Rep 14: 1519-1522, 2005.
APA
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D. ... Sun, X. (2005). Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis. Oncology Reports, 14, 1519-1522. https://doi.org/10.3892/or.14.6.1519
MLA
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D., Wang, M., Sun, X."Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis". Oncology Reports 14.6 (2005): 1519-1522.
Chicago
Zhang, J., Li, Q., Wang, D., Zhu, Z., Yang, Y., Cui, D., Wang, M., Sun, X."Up-regulation of PINCH in the stroma of oral squamous cell carcinoma predicts nodal metastasis". Oncology Reports 14, no. 6 (2005): 1519-1522. https://doi.org/10.3892/or.14.6.1519
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