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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 14 Issue 6

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Article

Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study

  • Authors:
    • I. Abdulkader
    • L. Sánchez
    • J. Cameselle-Teijeiro
    • F. Gude
    • J. E. Chávez
    • R. López-López
    • J. Forteza
    • M. Fraga

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Clinical University Hospital, 15706 Santiago de Compostela, Spain. ihab.abdulkader.nallib@sergas.es
  • Pages: 1527-1531
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1527
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Abstract

The development and progression of epithelial cancers are the result of an imbalance in signals promoting and inhibiting cellular proliferation and apoptosis. The aim of this study is to evaluate the expression of cell-cycle and apoptosis regulators and correlate them with clinical outcome in the most frequent carcinomas, in order to establish common prognostic biomarkers independent of cancer origin. Using tissue microarrays (TMAs), we have analysed the immuno-expression of Ki-67, Bcl-2, Bax, cyclin D1, cyclin D3, CDK1, CDK2, CDK6, p16, p21, and p27 in a series of 205 carcinomas of the large bowel, breast, lung and prostate (80, 73, 37 and 15 cases, respectively). By univariate analysis, positivity for p27, p16 and Bcl-2 was associated with better overall survival (P<0.0135, P<0.0442 and P<0.0001, respectively). The risk of mortality was 2.3-fold greater in patients without Bcl-2 expression. TMA immunohistochemical analysis identified a subset of epithelial cancers with overlapping alterations in cell-cycle checkpoints, apoptosis regulators and tumour suppressor pathways. We found that in most common epithelial cancers, regardless of origin, Bcl-2 appears to be the key biological factor influencing clinical behaviour.

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Copy and paste a formatted citation
Spandidos Publications style
Abdulkader I, Sánchez L, Cameselle-Teijeiro J, Gude F, Chávez JE, López-López R, Forteza J and Fraga M: Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study. Oncol Rep 14: 1527-1531, 2005.
APA
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J.E., López-López, R. ... Fraga, M. (2005). Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study. Oncology Reports, 14, 1527-1531. https://doi.org/10.3892/or.14.6.1527
MLA
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J. E., López-López, R., Forteza, J., Fraga, M."Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study". Oncology Reports 14.6 (2005): 1527-1531.
Chicago
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J. E., López-López, R., Forteza, J., Fraga, M."Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study". Oncology Reports 14, no. 6 (2005): 1527-1531. https://doi.org/10.3892/or.14.6.1527
Copy and paste a formatted citation
x
Spandidos Publications style
Abdulkader I, Sánchez L, Cameselle-Teijeiro J, Gude F, Chávez JE, López-López R, Forteza J and Fraga M: Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study. Oncol Rep 14: 1527-1531, 2005.
APA
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J.E., López-López, R. ... Fraga, M. (2005). Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study. Oncology Reports, 14, 1527-1531. https://doi.org/10.3892/or.14.6.1527
MLA
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J. E., López-López, R., Forteza, J., Fraga, M."Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study". Oncology Reports 14.6 (2005): 1527-1531.
Chicago
Abdulkader, I., Sánchez, L., Cameselle-Teijeiro, J., Gude, F., Chávez, J. E., López-López, R., Forteza, J., Fraga, M."Cell-cycle-associated markers and clinical outcome in human epithelial cancers: A tissue microarray study". Oncology Reports 14, no. 6 (2005): 1527-1531. https://doi.org/10.3892/or.14.6.1527
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