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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2005 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 14 Issue 6

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Article

Aberrant methylation: common in thymic carcinomas, rare in thymomas

  • Authors:
    • Makoto Suzuki
    • Hong Chen
    • Hisayuki Shigematsu
    • Soichiro Ando
    • Tomohiko Iida
    • Takahiro Nakajima
    • Takehiko Fujisawa
    • Hideki Kimura

  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Graduate School of Medicine, 1-8-1 Inohana, Chuoh-ku, Chiba 260-8677, Japan. smakoto@faculty.chiba-u.jp
  • Pages: 1621-1624
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/or.14.6.1621
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Abstract

Thymic carcinoma, which is a rare epithelial neoplasm of the thymus gland, is different from thymoma in its clinical and pathological features. To clarify the mechanism underlying the aggressive behavior of thymic carcinoma, we examined the clinicopathologic features, aberrant methylation patterns of the tumor suppressor genes, and epidermal growth factor receptor (EGFRs) mutation in both thymic carcinomas and thymomas. Clinical data of 11 thymic cancers and 13 thymomas were reviewed. Resected samples of 5 thymic cancers and 6 thymomas selected from 24 cases were used for methylation and mutation studies. Positive tumor markers were more frequent in thymic cancers than in thymomas (p=0.0233), and the methylation index, which reflects the overall methylation pattern, was significantly higher in thymic carcinomas (p=0.0053). No tumors showed a mutation of EGFR, KRAS, and HER2. Thymic carcinoma is distinct from thymoma not only with respect to clinicopathological features, but also aberrant methylation patterns of the tumor suppressor genes.

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki M, Chen H, Shigematsu H, Ando S, Iida T, Nakajima T, Fujisawa T and Kimura H: Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncol Rep 14: 1621-1624, 2005.
APA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T. ... Kimura, H. (2005). Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncology Reports, 14, 1621-1624. https://doi.org/10.3892/or.14.6.1621
MLA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14.6 (2005): 1621-1624.
Chicago
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14, no. 6 (2005): 1621-1624. https://doi.org/10.3892/or.14.6.1621
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki M, Chen H, Shigematsu H, Ando S, Iida T, Nakajima T, Fujisawa T and Kimura H: Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncol Rep 14: 1621-1624, 2005.
APA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T. ... Kimura, H. (2005). Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncology Reports, 14, 1621-1624. https://doi.org/10.3892/or.14.6.1621
MLA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14.6 (2005): 1621-1624.
Chicago
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14, no. 6 (2005): 1621-1624. https://doi.org/10.3892/or.14.6.1621
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