Aberrant methylation: common in thymic carcinomas, rare in thymomas

  • Authors:
    • Makoto Suzuki
    • Hong Chen
    • Hisayuki Shigematsu
    • Soichiro Ando
    • Tomohiko Iida
    • Takahiro Nakajima
    • Takehiko Fujisawa
    • Hideki Kimura
  • View Affiliations

  • Published online on: December 1, 2005     https://doi.org/10.3892/or.14.6.1621
  • Pages: 1621-1624
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Abstract

Thymic carcinoma, which is a rare epithelial neoplasm of the thymus gland, is different from thymoma in its clinical and pathological features. To clarify the mechanism underlying the aggressive behavior of thymic carcinoma, we examined the clinicopathologic features, aberrant methylation patterns of the tumor suppressor genes, and epidermal growth factor receptor (EGFRs) mutation in both thymic carcinomas and thymomas. Clinical data of 11 thymic cancers and 13 thymomas were reviewed. Resected samples of 5 thymic cancers and 6 thymomas selected from 24 cases were used for methylation and mutation studies. Positive tumor markers were more frequent in thymic cancers than in thymomas (p=0.0233), and the methylation index, which reflects the overall methylation pattern, was significantly higher in thymic carcinomas (p=0.0053). No tumors showed a mutation of EGFR, KRAS, and HER2. Thymic carcinoma is distinct from thymoma not only with respect to clinicopathological features, but also aberrant methylation patterns of the tumor suppressor genes.

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December 2005
Volume 14 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Suzuki M, Chen H, Shigematsu H, Ando S, Iida T, Nakajima T, Fujisawa T and Kimura H: Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncol Rep 14: 1621-1624, 2005
APA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T. ... Kimura, H. (2005). Aberrant methylation: common in thymic carcinomas, rare in thymomas. Oncology Reports, 14, 1621-1624. https://doi.org/10.3892/or.14.6.1621
MLA
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14.6 (2005): 1621-1624.
Chicago
Suzuki, M., Chen, H., Shigematsu, H., Ando, S., Iida, T., Nakajima, T., Fujisawa, T., Kimura, H."Aberrant methylation: common in thymic carcinomas, rare in thymomas". Oncology Reports 14, no. 6 (2005): 1621-1624. https://doi.org/10.3892/or.14.6.1621