Antitumor effects of IDN5109 on head and neck squamous cell carcinoma

  • Authors:
    • Daisuke Sano
    • Hideki Matsuda
    • Yukari Ishiguro
    • Goshi Nishimura
    • Mariko Kawakami
    • Mamoru Tsukuda
  • View Affiliations

  • Published online on: February 1, 2006     https://doi.org/10.3892/or.15.2.329
  • Pages: 329-334
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Taxanes, a new class of antitumor drugs, are effective against a large number of human tumors, although there are problems with drug resistance. The novel taxane, IDN5109, is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. We investigated the cellular response of IDN5109 to head and neck squamous cell carcinoma (HNSCC), and compared the antitumor activity of IDN5109 with that of paclitaxel. This is the first demonstration of antitumor effects of IDN5109 on HNSCC. In in vitro experiments, IDN5109 showed antiproliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was up-regulated, and caspase-3 was activated. After treatment with IDN5109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. Immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC.

Related Articles

Journal Cover

February 2006
Volume 15 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sano D, Matsuda H, Ishiguro Y, Nishimura G, Kawakami M and Tsukuda M: Antitumor effects of IDN5109 on head and neck squamous cell carcinoma. Oncol Rep 15: 329-334, 2006
APA
Sano, D., Matsuda, H., Ishiguro, Y., Nishimura, G., Kawakami, M., & Tsukuda, M. (2006). Antitumor effects of IDN5109 on head and neck squamous cell carcinoma. Oncology Reports, 15, 329-334. https://doi.org/10.3892/or.15.2.329
MLA
Sano, D., Matsuda, H., Ishiguro, Y., Nishimura, G., Kawakami, M., Tsukuda, M."Antitumor effects of IDN5109 on head and neck squamous cell carcinoma". Oncology Reports 15.2 (2006): 329-334.
Chicago
Sano, D., Matsuda, H., Ishiguro, Y., Nishimura, G., Kawakami, M., Tsukuda, M."Antitumor effects of IDN5109 on head and neck squamous cell carcinoma". Oncology Reports 15, no. 2 (2006): 329-334. https://doi.org/10.3892/or.15.2.329