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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2006 Volume 15 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8

  • Authors:
    • M. Josefa Bello
    • Jose M. De Campos
    • Alberto Isla
    • Cacilda Casartelli
    • Juan A. Rey

  • View Affiliations / Copyright

    Affiliations: Unidad de Investigacion, Laboratorio Oncogenetica Molecular y Epigenetica del Cancer, Hospital Universitario La Paz, Paseo Castellana 261, 28046 Madrid, Spain
  • Pages: 443-448
    |
    Published online on: February 1, 2006
       https://doi.org/10.3892/or.15.2.443
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Abstract

The epigenetic changes in pituitary adenomas were identified by evaluating the methylation status of nine genes (RB1, p14ARF, p16INK4a, p73, TIMP-3, MGMT, DAPK, THBS1 and caspase-8) in a series of 35 tumours using methylation-specific PCR analysis plus sequencing. The series included non-functional adenomas (n=23), prolactinomas (n=6), prolactinoma plus thyroid-stimulating hormone adenoma (n=1), growth hormone adenomas (n=4), and adrenocorticotropic adenoma (n=1). All of the tumours had methylation of at least one of these genes and 40% of samples (14 of 35) displayed concurrent methylation of at least three genes. The frequencies of aberrant methylation were: 20% for RB1, 17% for p14ARF, 34% for p16INK4a, 29% for p73, 11% for TIMP-3, 23% for MGMT, 6% for DAPK, 43% for THBS1 and 54% for caspase-8. No aberrant methylation was observed in two non-malignant pituitary samples from healthy controls. Although some differences in the frequency of gene methylation between functional and non-functional adenomas were detected, these differences did not reach statistical significance. Our results suggest that promoter methylation is a frequent event in pituitary adenoma tumourigenesis, a process in which inactivation of apoptosis-related genes (DAPK, caspase-8) might play a key role.

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Copy and paste a formatted citation
Spandidos Publications style
Bello MJ, De Campos JM, Isla A, Casartelli C and Rey JA: Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8. Oncol Rep 15: 443-448, 2006.
APA
Bello, M.J., De Campos, J.M., Isla, A., Casartelli, C., & Rey, J.A. (2006). Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8. Oncology Reports, 15, 443-448. https://doi.org/10.3892/or.15.2.443
MLA
Bello, M. J., De Campos, J. M., Isla, A., Casartelli, C., Rey, J. A."Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8". Oncology Reports 15.2 (2006): 443-448.
Chicago
Bello, M. J., De Campos, J. M., Isla, A., Casartelli, C., Rey, J. A."Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8". Oncology Reports 15, no. 2 (2006): 443-448. https://doi.org/10.3892/or.15.2.443
Copy and paste a formatted citation
x
Spandidos Publications style
Bello MJ, De Campos JM, Isla A, Casartelli C and Rey JA: Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8. Oncol Rep 15: 443-448, 2006.
APA
Bello, M.J., De Campos, J.M., Isla, A., Casartelli, C., & Rey, J.A. (2006). Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8. Oncology Reports, 15, 443-448. https://doi.org/10.3892/or.15.2.443
MLA
Bello, M. J., De Campos, J. M., Isla, A., Casartelli, C., Rey, J. A."Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8". Oncology Reports 15.2 (2006): 443-448.
Chicago
Bello, M. J., De Campos, J. M., Isla, A., Casartelli, C., Rey, J. A."Promoter CpG methylation of multiple genes in pituitary adenomas: frequent involvement of caspase-8". Oncology Reports 15, no. 2 (2006): 443-448. https://doi.org/10.3892/or.15.2.443
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