The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer

  • Authors:
    • Yutaka Ogata
    • Keiko Matono
    • Tomoaki Mizobe
    • Nobuya Ishibashi
    • Shinjiro Mori
    • Yoshito Akagi
    • Satoru Ikeda
    • Hiroyuki Ozasa
    • Hidetsugu Murakami
    • Kazuo Shirouzu
  • View Affiliations

  • Published online on: May 1, 2006     https://doi.org/10.3892/or.15.5.1111
  • Pages: 1111-1116
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Abstract

The aim of this study was to determine any correlation between the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines and the vascular endothelial growth factor (VEGF) expression in primary colorectal cancer tissues. The data were reviewed retrospectively on 342 patients with colorectal cancer at stage II or III, who underwent potentially curative resection between 1988 and 1998. Of these, 225 received post-operative administration of oral fluoropyrimidines such as UFT and 5'-DFUR, while the other 117 patients underwent surgery alone. Immunostaining for VEGF was performed using colorectal tumours. Overall, VEGF was positively expressed in primary tumour cells in 48% of patients. The disease-free survival rate and the overall survival rate in the chemotherapy group were higher than those in the surgery-alone group, although not significantly. However, the disease-free survival rate and the overall survival rate were similar between the two groups in patients with a tumour positive for VEGF. Multivariate analysis revealed that the VEGF expression was an independent factor for post-operative recurrence, and the VEGF expression and post-operative adjuvant chemotherapy were an independent factor for overall survival, in addition to the lymph node metastasis and the venous invasion. In conclusion, the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines may not be as great for patients with a tumour positive for VEGF having a greater risk of post-operative recurrence. The results support further investigation on efficacy of molecular targeting therapy for VEGF in combination with oral fluoropyrimidines as post-operative adjuvant therapy in colorectal cancer positive for VEGF.

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May 2006
Volume 15 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ogata Y, Matono K, Mizobe T, Ishibashi N, Mori S, Akagi Y, Ikeda S, Ozasa H, Murakami H, Shirouzu K, Shirouzu K, et al: The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. Oncol Rep 15: 1111-1116, 2006
APA
Ogata, Y., Matono, K., Mizobe, T., Ishibashi, N., Mori, S., Akagi, Y. ... Shirouzu, K. (2006). The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer. Oncology Reports, 15, 1111-1116. https://doi.org/10.3892/or.15.5.1111
MLA
Ogata, Y., Matono, K., Mizobe, T., Ishibashi, N., Mori, S., Akagi, Y., Ikeda, S., Ozasa, H., Murakami, H., Shirouzu, K."The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer". Oncology Reports 15.5 (2006): 1111-1116.
Chicago
Ogata, Y., Matono, K., Mizobe, T., Ishibashi, N., Mori, S., Akagi, Y., Ikeda, S., Ozasa, H., Murakami, H., Shirouzu, K."The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer". Oncology Reports 15, no. 5 (2006): 1111-1116. https://doi.org/10.3892/or.15.5.1111