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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2006 Volume 15 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study

  • Authors:
    • George P. Stathopoulos
    • Teni Boulikas
    • Maria Vougiouka
    • Sotirios K. Rigatos
    • John G. Stathopoulos

  • View Affiliations / Copyright

    Affiliations: Errikos Dunant Hospital and Medical School of Athens, 115 28 Athens, Greece. dr-gps@ath.forthnet.gr
  • Pages: 1201-1204
    |
    Published online on: May 1, 2006
       https://doi.org/10.3892/or.15.5.1201
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Abstract

The present trial is a phase I-II study based on a new liposomal cisplatin (lipoplatin). Previous preclinical and clinical data (phase I pharmacokinetics) led to the investigation of a combined treatment modality involving lipoplatin and gemcitabine. The gemcitabine dose was kept standard at 1000 mg/m2 and the lipoplatin dose was escalated from 25 mg/m2 to 125 mg/m2. The treatment was administered to advanced pretreated pancreatic cancer patients who were refractory to previous chemotherapy which included gemcitabine. Lipoplatin at 125 mg/m2 was defined as dose limiting toxicity (DLT) and 100 mg/m2 as the maximum tolerated dose (MTD) in combination with 1000 mg/m2 of gemcitabine. Preliminary objective response rate data showed a partial response in 2/24 patients (8.3%), disease stability in 14 patients (58.3%) for a median duration of 3 months (range 2-7 months) and clinical benefit in 8 patients (33.3%). Liposomal cisplatin is a non-toxic alternative agent to bare cisplatin. In combination with gemcitabine, it has an MTD of 100 mg/m2 and shows promising efficacy in refractory pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Stathopoulos GP, Boulikas T, Vougiouka M, Rigatos SK and Stathopoulos JG: Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study. Oncol Rep 15: 1201-1204, 2006.
APA
Stathopoulos, G.P., Boulikas, T., Vougiouka, M., Rigatos, S.K., & Stathopoulos, J.G. (2006). Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study. Oncology Reports, 15, 1201-1204. https://doi.org/10.3892/or.15.5.1201
MLA
Stathopoulos, G. P., Boulikas, T., Vougiouka, M., Rigatos, S. K., Stathopoulos, J. G."Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study". Oncology Reports 15.5 (2006): 1201-1204.
Chicago
Stathopoulos, G. P., Boulikas, T., Vougiouka, M., Rigatos, S. K., Stathopoulos, J. G."Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study". Oncology Reports 15, no. 5 (2006): 1201-1204. https://doi.org/10.3892/or.15.5.1201
Copy and paste a formatted citation
x
Spandidos Publications style
Stathopoulos GP, Boulikas T, Vougiouka M, Rigatos SK and Stathopoulos JG: Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study. Oncol Rep 15: 1201-1204, 2006.
APA
Stathopoulos, G.P., Boulikas, T., Vougiouka, M., Rigatos, S.K., & Stathopoulos, J.G. (2006). Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study. Oncology Reports, 15, 1201-1204. https://doi.org/10.3892/or.15.5.1201
MLA
Stathopoulos, G. P., Boulikas, T., Vougiouka, M., Rigatos, S. K., Stathopoulos, J. G."Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study". Oncology Reports 15.5 (2006): 1201-1204.
Chicago
Stathopoulos, G. P., Boulikas, T., Vougiouka, M., Rigatos, S. K., Stathopoulos, J. G."Liposomal cisplatin combined with gemcitabine in pretreated advanced pancreatic cancer patients: A phase I-II study". Oncology Reports 15, no. 5 (2006): 1201-1204. https://doi.org/10.3892/or.15.5.1201
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