Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer

  • Authors:
    • Carl C. Schimanski
    • Rüdiger Bahre
    • Ines Gockel
    • Theodor Junginger
    • Nektaria Simiantonaki
    • Stefan Biesterfeld
    • Tobias Achenbach
    • Thomas Wehler
    • Peter R. Galle
    • Markus Moehler
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/or.16.1.109
  • Pages: 109-113
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Abstract

Despite many pathophysiological analyses, the process of tumor dissemination of hepatocellular carcinoma (HCC) remains vague. In diverse tumor entities, expression of the chemokine receptor, CCR7, has been linked to tumor dissemination and poor prognosis. Therefore, we evaluated, whether CCR7 exerts similar effects in human HCC. CCR7 expression analysis was performed in vitro on human hepatoma cell lines (Huh7, Hep3B, wt HepG2, p53 dominant negative transfected HepG2). In addition, CCR7 expression was evaluated in 39 patients with hepatocellular cancer and correlated with both, tumor and patients characteristics. Human hepatocellular carcinoma samples and hepatoma cell lines displayed variable intensities of CCR7 expression. In patients, CCR7 expression was significantly associated with progressed local tumors (P=0.02) and lymphatic metastasis (P=0.02). Strong expression of CCR7 promotes intrahepatic and lymphatic HCC dissemination.

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July 2006
Volume 16 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Schimanski CC, Bahre R, Gockel I, Junginger T, Simiantonaki N, Biesterfeld S, Achenbach T, Wehler T, Galle PR, Moehler M, Moehler M, et al: Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. Oncol Rep 16: 109-113, 2006.
APA
Schimanski, C.C., Bahre, R., Gockel, I., Junginger, T., Simiantonaki, N., Biesterfeld, S. ... Moehler, M. (2006). Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. Oncology Reports, 16, 109-113. https://doi.org/10.3892/or.16.1.109
MLA
Schimanski, C. C., Bahre, R., Gockel, I., Junginger, T., Simiantonaki, N., Biesterfeld, S., Achenbach, T., Wehler, T., Galle, P. R., Moehler, M."Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer". Oncology Reports 16.1 (2006): 109-113.
Chicago
Schimanski, C. C., Bahre, R., Gockel, I., Junginger, T., Simiantonaki, N., Biesterfeld, S., Achenbach, T., Wehler, T., Galle, P. R., Moehler, M."Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer". Oncology Reports 16, no. 1 (2006): 109-113. https://doi.org/10.3892/or.16.1.109