Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients

  • Authors:
    • Shogo Sasao
    • Toru Hiyama
    • Shinji Tanaka
    • Masaharu Yoshihara
    • Wataru Yasui
    • Kazuaki Chayama
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/or.16.1.11
  • Pages: 11-15
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Abstract

The pathways of gastric cancer in young patients (40 years of age or younger) have not yet been determined. We therefore examined clinicopathologically and genetically 68 gastric cancers in young patients and 66 tumors in older patients (41 years of age or older). Mutations in B-raf and K-ras were identified by PCR-SSCP following sequencing. Microsatellite instability (MSI) and hMLH3 mutations were also examined. Histopathologically, diffuse-type gastric cancer and cancer in the whole of the stomach were found significantly more often in young patients than in older patients (21% vs. 2%, P=0.0006, and 77% vs. 32%, P<0.0001, respectively). Genetically, MSI and hMLH3 mutations were found significantly more often in tumors in young patients than in tumors in older patients (15% vs. 4%, P=0.040, and 9% vs. 0%, P=0.036, respectively). Tumors in young female patients were found significantly less often in the lower-third of the stomach and showed a significantly greater frequency of MSI, compared to tumors in young male patients (33% vs. 9%, P=0.046, 5% vs. 30%, P=0.010, respectively). These results suggest that the pathways of gastric carcinogenesis differ between young patients and older patients, and that the pathways differ between the sexes in young patients.

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July 2006
Volume 16 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sasao S, Hiyama T, Tanaka S, Yoshihara M, Yasui W and Chayama K: Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients. Oncol Rep 16: 11-15, 2006
APA
Sasao, S., Hiyama, T., Tanaka, S., Yoshihara, M., Yasui, W., & Chayama, K. (2006). Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients. Oncology Reports, 16, 11-15. https://doi.org/10.3892/or.16.1.11
MLA
Sasao, S., Hiyama, T., Tanaka, S., Yoshihara, M., Yasui, W., Chayama, K."Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients". Oncology Reports 16.1 (2006): 11-15.
Chicago
Sasao, S., Hiyama, T., Tanaka, S., Yoshihara, M., Yasui, W., Chayama, K."Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients". Oncology Reports 16, no. 1 (2006): 11-15. https://doi.org/10.3892/or.16.1.11