The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients

  • Authors:
    • Magdalena Ignaszak-Szczepaniak
    • Wanda Horst-Sikorska
    • Joanna Sawicka
    • Marta Kaczmarek
    • Ryszard Slomski
  • View Affiliations

  • Published online on: July 1, 2006     https://doi.org/10.3892/or.16.1.65
  • Pages: 65-71
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The TP53 polymorphism occurs at codon 72 of exon 4 with two alleles encoding either arginine or proline. The association between this common polymorphism and risk of different cancers has been extensive studied, however various reports are controversial. We have analyzed the 72Pro polymorphic variant in patients with adrenocortical tumors to evaluate whether 72G↷C substitution at codon 72 of TP53 gene may be associated with increased risk for malignancy in adrenal cortex in comparison to the control group. DNA extracted from peripheral leucocytes of 46 Polish patients with adrenocortical tumors (17 malignant and 29 benign) and 50 controls was examined by PCR-HD method followed by direct sequencing. TP53 polymorphism in codon 72 was found in 47% of ACC cases, in 28% of patients with adenomas and in 24% of controls. The genotype Arg/Arg, Arg/Pro and Pro/Pro distribution was respectively 53%/ 35%/12% for cancers, 72%/28%/0% for benign tumors and 76%/24%/0% for controls. High frequency of 72Pro allele in patients with carcinoma (29%) in comparison to the benign tumors (14%) and controls (12%) was statistically analyzed. We found that 72Pro variant of TP53 gene was associated with a significantly increased risk of ACC (OR = 3.05; 95% CI = 1.17-7.91, p=0.03). Our results suggest that the TP53 codon 72 polymorphism could be associated with susceptibility for adrenocortical cancer in the examined Polish patients.

Related Articles

Journal Cover

July 2006
Volume 16 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ignaszak-Szczepaniak M, Horst-Sikorska W, Sawicka J, Kaczmarek M and Slomski R: The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients. Oncol Rep 16: 65-71, 2006
APA
Ignaszak-Szczepaniak, M., Horst-Sikorska, W., Sawicka, J., Kaczmarek, M., & Slomski, R. (2006). The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients. Oncology Reports, 16, 65-71. https://doi.org/10.3892/or.16.1.65
MLA
Ignaszak-Szczepaniak, M., Horst-Sikorska, W., Sawicka, J., Kaczmarek, M., Slomski, R."The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients". Oncology Reports 16.1 (2006): 65-71.
Chicago
Ignaszak-Szczepaniak, M., Horst-Sikorska, W., Sawicka, J., Kaczmarek, M., Slomski, R."The TP53 codon 72 polymorphism and predisposition to adrenocortical cancer in Polish patients". Oncology Reports 16, no. 1 (2006): 65-71. https://doi.org/10.3892/or.16.1.65