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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2006 Volume 16 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells

  • Authors:
    • Osamu Maeda
    • Masashi Kondo
    • Takayoshi Fujita
    • Noriyasu Usami
    • Takayuki Fukui
    • Kaoru Shimokata
    • Takafumi Ando
    • Hidemi Goto
    • Yoshitaka Sekido

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8550, Japan
  • Pages: 91-96
    |
    Published online on: July 1, 2006
       https://doi.org/10.3892/or.16.1.91
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Abstract

The Hedgehog (Hh) signaling pathway and the Wnt signaling pathway are known to play important roles in carcinogenesis and the progression of various human malignant tumors. Although a relationship between these two pathways has recently been reported, the mechanism by which β-catenin, one of the key molecules of the Wnt signaling pathway, influences the Hh pathway has not yet been revealed in detail. To clarify the role of β-catenin in relation to the Hh signaling pathway, we transfected GLI1 and β-catenin expression constructs into human malignant cells, including stomach, colon, and lung cancers, and evaluated the luciferase activity of GLI-responsive reporter constructs. While exogenous GLI1 increased the luciferase activity, exogenous β-catenin also enhanced the activity under overexpression of GLI1. However, co-transfection with T-cell factor (TCF)-4 or lymphocyte enhancer factor (LEF)-1 did not influence the activity, indicating that the enhancement of β-catenin in relation to the Hh signaling pathway is not TCF/LEF-dependent. Our results suggest that β-catenin might be involved in the Hh signaling pathway via enhancement of the transcriptional activity of GLI.

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Copy and paste a formatted citation
Spandidos Publications style
Maeda O, Kondo M, Fujita T, Usami N, Fukui T, Shimokata K, Ando T, Goto H and Sekido Y: Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells. Oncol Rep 16: 91-96, 2006.
APA
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K. ... Sekido, Y. (2006). Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells. Oncology Reports, 16, 91-96. https://doi.org/10.3892/or.16.1.91
MLA
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K., Ando, T., Goto, H., Sekido, Y."Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells". Oncology Reports 16.1 (2006): 91-96.
Chicago
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K., Ando, T., Goto, H., Sekido, Y."Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells". Oncology Reports 16, no. 1 (2006): 91-96. https://doi.org/10.3892/or.16.1.91
Copy and paste a formatted citation
x
Spandidos Publications style
Maeda O, Kondo M, Fujita T, Usami N, Fukui T, Shimokata K, Ando T, Goto H and Sekido Y: Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells. Oncol Rep 16: 91-96, 2006.
APA
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K. ... Sekido, Y. (2006). Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells. Oncology Reports, 16, 91-96. https://doi.org/10.3892/or.16.1.91
MLA
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K., Ando, T., Goto, H., Sekido, Y."Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells". Oncology Reports 16.1 (2006): 91-96.
Chicago
Maeda, O., Kondo, M., Fujita, T., Usami, N., Fukui, T., Shimokata, K., Ando, T., Goto, H., Sekido, Y."Enhancement of GLI1-transcriptional activity by β-catenin in human cancer cells". Oncology Reports 16, no. 1 (2006): 91-96. https://doi.org/10.3892/or.16.1.91
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