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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2006 Volume 16 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2006 Volume 16 Issue 2

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Article

Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer

  • Authors:
    • Takashi Oshima
    • Roppei Yamada
    • Shinsuke Hatori
    • Chikara Kunisaki
    • Toshio Imada
  • View Affiliations / Copyright

    Affiliations: Gastroenterological Center, Yokohama City University Medical Center, Yokohama 232-0024, Japan. ohshimatakashi@yahoo.co.jp
  • Pages: 361-366
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/or.16.2.361
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Abstract

The response of gastric cancer with peritoneal dissemination to systemic chemotherapy may be negatively affected by poor drug delivery due to the blood-peritoneal barrier. However, S-1 has been reported to be effective. We examined the pharmacokinetics of S-1 in 14 patients who had gastric cancer with peritoneal dissemination. S-1 was given from the morning of the day before surgery to the morning of surgery. Concentrations of 5-fluorouracil (5-FU) and gimeracil (CDHP) were measured in the serum, ascites, disseminated peritoneal nodes, and normal peritoneum. There was a strong correlation between 5-FU and CDHP concentrations in peritoneal tissues. The concentrations of 5-FU and CDHP in the serum were similar to those in ascites. The concentration of 5-FU was significantly higher in disseminated nodes than in the normal peritoneum. After administration of S-1 to gastric cancer patients with peritoneal dissemination, 5-FU and CDHP in the serum linearly pass through the peritoneum and enter the ascites. High concentrations of 5-FU selectively penetrate disseminated peritoneal cells.

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Copy and paste a formatted citation
Spandidos Publications style
Oshima T, Yamada R, Hatori S, Kunisaki C and Imada T: Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncol Rep 16: 361-366, 2006.
APA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., & Imada, T. (2006). Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncology Reports, 16, 361-366. https://doi.org/10.3892/or.16.2.361
MLA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16.2 (2006): 361-366.
Chicago
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16, no. 2 (2006): 361-366. https://doi.org/10.3892/or.16.2.361
Copy and paste a formatted citation
x
Spandidos Publications style
Oshima T, Yamada R, Hatori S, Kunisaki C and Imada T: Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncol Rep 16: 361-366, 2006.
APA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., & Imada, T. (2006). Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncology Reports, 16, 361-366. https://doi.org/10.3892/or.16.2.361
MLA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16.2 (2006): 361-366.
Chicago
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16, no. 2 (2006): 361-366. https://doi.org/10.3892/or.16.2.361
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