Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer

  • Authors:
    • Takashi Oshima
    • Roppei Yamada
    • Shinsuke Hatori
    • Chikara Kunisaki
    • Toshio Imada
  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/or.16.2.361
  • Pages: 361-366
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Abstract

The response of gastric cancer with peritoneal dissemination to systemic chemotherapy may be negatively affected by poor drug delivery due to the blood-peritoneal barrier. However, S-1 has been reported to be effective. We examined the pharmacokinetics of S-1 in 14 patients who had gastric cancer with peritoneal dissemination. S-1 was given from the morning of the day before surgery to the morning of surgery. Concentrations of 5-fluorouracil (5-FU) and gimeracil (CDHP) were measured in the serum, ascites, disseminated peritoneal nodes, and normal peritoneum. There was a strong correlation between 5-FU and CDHP concentrations in peritoneal tissues. The concentrations of 5-FU and CDHP in the serum were similar to those in ascites. The concentration of 5-FU was significantly higher in disseminated nodes than in the normal peritoneum. After administration of S-1 to gastric cancer patients with peritoneal dissemination, 5-FU and CDHP in the serum linearly pass through the peritoneum and enter the ascites. High concentrations of 5-FU selectively penetrate disseminated peritoneal cells.

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August 2006
Volume 16 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Oshima T, Yamada R, Hatori S, Kunisaki C and Imada T: Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncol Rep 16: 361-366, 2006
APA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., & Imada, T. (2006). Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer. Oncology Reports, 16, 361-366. https://doi.org/10.3892/or.16.2.361
MLA
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16.2 (2006): 361-366.
Chicago
Oshima, T., Yamada, R., Hatori, S., Kunisaki, C., Imada, T."Pharmacokinetics of S-1 in patients with peritoneal dissemination of gastric cancer". Oncology Reports 16, no. 2 (2006): 361-366. https://doi.org/10.3892/or.16.2.361