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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2006 Volume 16 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer

  • Authors:
    • Hiromichi Sonoda
    • Kazuo Yamamoto
    • Ryoji Kushima
    • Hiroshi Yamamoto
    • Hiroyuki Naitoh
    • Hidetoshi Okabe
    • Tohru Tani

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Shiga University of Medical Science, Shiga 520-2192, Japan. hirosono@belle.shiga-med.ac.jp
  • Pages: 411-416
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/or.16.2.411
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Abstract

We previously reported that MUC2 is a useful marker in the detection of lymph node micrometastasis (LMM) in gastric cancer. To improve the detection rate, we focused on a TFF1 gene. We used the duplex reverse transcriptase-polymerase chain reaction (RT-PCR) method with MUC2 and TFF1 genes to detect LMM in histologically node negative (pN0) early gastric cancer (EGC) and evaluated their effectiveness. A total of 310 lymph nodes from 33 patients with pN0 EGC were analyzed. All carcinoma specimens were positive for MUC2 and/or TFF1. The positive rate of TFF1 was significantly higher than MUC2 in the undifferentiated carcinoma specimens (p=0.002). The detection rate of duplex RT-PCR with MUC2 and TFF1 was higher than that of MUC2 or TFF1 alone. In mucosal cancer, 7 cases were positive for duplex RT-PCR. Of these 7 cases, 3 were MUC2-positive/TFF1-negative while 4 were MUC2-negative/TFF1-positive. LMMs were not detected in elevated-type primary mucosal cancers with a 20-30-mm diameter. The duplex RT-PCR assay with both MUC2 and TFF1 provides a higher LMM detection rate than either MUC2 or TFF1 alone, especially in mucosal gastric cancer. LMM detected in this manner may prove useful in broadening the indications for endoscopic mucosal resection in elevated-type cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Sonoda H, Yamamoto K, Kushima R, Yamamoto H, Naitoh H, Okabe H and Tani T: Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer. Oncol Rep 16: 411-416, 2006.
APA
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., & Tani, T. (2006). Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer. Oncology Reports, 16, 411-416. https://doi.org/10.3892/or.16.2.411
MLA
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., Tani, T."Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer". Oncology Reports 16.2 (2006): 411-416.
Chicago
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., Tani, T."Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer". Oncology Reports 16, no. 2 (2006): 411-416. https://doi.org/10.3892/or.16.2.411
Copy and paste a formatted citation
x
Spandidos Publications style
Sonoda H, Yamamoto K, Kushima R, Yamamoto H, Naitoh H, Okabe H and Tani T: Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer. Oncol Rep 16: 411-416, 2006.
APA
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., & Tani, T. (2006). Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer. Oncology Reports, 16, 411-416. https://doi.org/10.3892/or.16.2.411
MLA
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., Tani, T."Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer". Oncology Reports 16.2 (2006): 411-416.
Chicago
Sonoda, H., Yamamoto, K., Kushima, R., Yamamoto, H., Naitoh, H., Okabe, H., Tani, T."Detection of lymph node micrometastasis in pN0 early gastric cancer: Efficacy of duplex RT-PCR with MUC2 and TFF1 in mucosal cancer". Oncology Reports 16, no. 2 (2006): 411-416. https://doi.org/10.3892/or.16.2.411
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