Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx

  • Authors:
    • Agnieszka Stembalska
    • Nikolaus Blin
    • David Ramsey
    • Maria M. Sasiadek
  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/or.16.2.417
  • Pages: 417-421
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Abstract

Genetic etiology of squamous cell carcinoma of the larynx (SCCL) is very complex, with both molecular and chromosomal alterations involved. The target genes have not yet been clearly identified. Therefore, our study focused on searching for regions that potentially harbor genes related to SCCL. After comparative genomic hybridization (CGH) analysis of a set of 52 SCCL we specified 13q21-q32 and 13q34 as the most frequently deleted regions. In order to precisely map the critical region of deletion, we studied these areas by using 15 microsatellite markers. In our material a significantly high frequency of loss of heterozygosity (LOH) (test for a difference in two proportions, p<0.001) was observed for the following markers: D13S1320 (13q21.1), D13S800 (13q21.3), D13S1818 (13q32.1), D13S770 (13q32.3) and D13S285 (13q34). Three hot spots of LOH were found: 13q21.1-q22.1 (D13S1320-D13S1824-D13S800-SHGC30014- WI-16413-D13S1186), 13q.31.1-13q32.3 (D13S317-D13S1818-D13S770), 13q34 (D13S285). Among these areas, 13q31.1-q32.3 was identified as new hot spot of deletion in SCCLs.

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August 2006
Volume 16 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Stembalska A, Blin N, Ramsey D and Sasiadek MM: Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncol Rep 16: 417-421, 2006
APA
Stembalska, A., Blin, N., Ramsey, D., & Sasiadek, M.M. (2006). Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncology Reports, 16, 417-421. https://doi.org/10.3892/or.16.2.417
MLA
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16.2 (2006): 417-421.
Chicago
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16, no. 2 (2006): 417-421. https://doi.org/10.3892/or.16.2.417