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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2006 Volume 16 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx

  • Authors:
    • Agnieszka Stembalska
    • Nikolaus Blin
    • David Ramsey
    • Maria M. Sasiadek

  • View Affiliations / Copyright

    Affiliations: Department of Genetics, Wroclaw Medical University, Wroclaw 50-368, Poland
  • Pages: 417-421
    |
    Published online on: August 1, 2006
       https://doi.org/10.3892/or.16.2.417
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Abstract

Genetic etiology of squamous cell carcinoma of the larynx (SCCL) is very complex, with both molecular and chromosomal alterations involved. The target genes have not yet been clearly identified. Therefore, our study focused on searching for regions that potentially harbor genes related to SCCL. After comparative genomic hybridization (CGH) analysis of a set of 52 SCCL we specified 13q21-q32 and 13q34 as the most frequently deleted regions. In order to precisely map the critical region of deletion, we studied these areas by using 15 microsatellite markers. In our material a significantly high frequency of loss of heterozygosity (LOH) (test for a difference in two proportions, p<0.001) was observed for the following markers: D13S1320 (13q21.1), D13S800 (13q21.3), D13S1818 (13q32.1), D13S770 (13q32.3) and D13S285 (13q34). Three hot spots of LOH were found: 13q21.1-q22.1 (D13S1320-D13S1824-D13S800-SHGC30014- WI-16413-D13S1186), 13q.31.1-13q32.3 (D13S317-D13S1818-D13S770), 13q34 (D13S285). Among these areas, 13q31.1-q32.3 was identified as new hot spot of deletion in SCCLs.

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Copy and paste a formatted citation
Spandidos Publications style
Stembalska A, Blin N, Ramsey D and Sasiadek MM: Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncol Rep 16: 417-421, 2006.
APA
Stembalska, A., Blin, N., Ramsey, D., & Sasiadek, M.M. (2006). Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncology Reports, 16, 417-421. https://doi.org/10.3892/or.16.2.417
MLA
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16.2 (2006): 417-421.
Chicago
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16, no. 2 (2006): 417-421. https://doi.org/10.3892/or.16.2.417
Copy and paste a formatted citation
x
Spandidos Publications style
Stembalska A, Blin N, Ramsey D and Sasiadek MM: Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncol Rep 16: 417-421, 2006.
APA
Stembalska, A., Blin, N., Ramsey, D., & Sasiadek, M.M. (2006). Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx. Oncology Reports, 16, 417-421. https://doi.org/10.3892/or.16.2.417
MLA
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16.2 (2006): 417-421.
Chicago
Stembalska, A., Blin, N., Ramsey, D., Sasiadek, M. M."Three distinct regions of deletion on 13q in squamous cell carcinoma of the larynx". Oncology Reports 16, no. 2 (2006): 417-421. https://doi.org/10.3892/or.16.2.417
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