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Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa

  • Authors:
    • V. Tugnoli
    • A. Mucci
    • L. Schenetti
    • V. Righi
    • C. Calabrese
    • A. Fabbri
    • G. Di Febo
    • M. R. Tosi

  • View Affiliations

  • Published online on: September 1, 2006     https://doi.org/10.3892/or.16.3.543
  • Pages: 543-553
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Abstract

The present study reports the characteristics of the biochemical profile of human gastric adenocarcinoma in comparison with that of healthy gastric mucosa, using ex vivo HR-MAS Magnetic Resonance Spectroscopy. Healthy human mucosa is mainly characterized by the presence of small metabolites (more than 50 identified) and macromolecules, whereas the adenocarcinoma spectra are dominated by the presence of signals due to triglycerides, whose content on the contrary is very low in healthy gastric mucosa. The use of spin-echo experiments enable us to detect some metabolites in the unhealthy tissues and to determine their variation with respect to the healthy ones. We have observed that the Cho__AMB__colon;ChoCC ratio changes from 20__AMB__colon;80 in the healthy tissues to 80__AMB__colon;20 in the neoplastic gastric mucosa.

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September 2006
Volume 16 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Tugnoli V, Mucci A, Schenetti L, Righi V, Calabrese C, Fabbri A, Di Febo G and Tosi MR: Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa. Oncol Rep 16: 543-553, 2006
APA
Tugnoli, V., Mucci, A., Schenetti, L., Righi, V., Calabrese, C., Fabbri, A. ... Tosi, M.R. (2006). Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa. Oncology Reports, 16, 543-553. https://doi.org/10.3892/or.16.3.543
MLA
Tugnoli, V., Mucci, A., Schenetti, L., Righi, V., Calabrese, C., Fabbri, A., Di Febo, G., Tosi, M. R."Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa". Oncology Reports 16.3 (2006): 543-553.
Chicago
Tugnoli, V., Mucci, A., Schenetti, L., Righi, V., Calabrese, C., Fabbri, A., Di Febo, G., Tosi, M. R."Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa". Oncology Reports 16, no. 3 (2006): 543-553. https://doi.org/10.3892/or.16.3.543