Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer

  • Authors:
    • Wilko I. Staiger
    • Johannes F. Coy
    • Rainer Grobholz
    • Ralf-Dieter Hofheinz
    • Nadine Lukan
    • Stefan Post
    • Matthias H. Schwarzbach
    • Frank Willeke
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/or.16.4.657
  • Pages: 657-661
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Abstract

The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We detected a strong upregulation of the mutated transketolase transcript (TKTL1) in a considerable number of patients with gastric cancer (GC) or cancer of the gastroesophageal junction (GEJ). While only 10.8% of the cancer tissues revealed a significant mRNA upregulation, 36.9% of the cancer tissues demonstrated a protein overexpression. We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth. Since molecular targeted inhibition of transketolase enzyme reactions suppresses tumor growth and metastasis, TKTL1 could be a relevant target for anti-transketolase therapies in gastric cancer.

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October 2006
Volume 16 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Staiger WI, Coy JF, Grobholz R, Hofheinz R, Lukan N, Post S, Schwarzbach MH and Willeke F: Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncol Rep 16: 657-661, 2006
APA
Staiger, W.I., Coy, J.F., Grobholz, R., Hofheinz, R., Lukan, N., Post, S. ... Willeke, F. (2006). Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncology Reports, 16, 657-661. https://doi.org/10.3892/or.16.4.657
MLA
Staiger, W. I., Coy, J. F., Grobholz, R., Hofheinz, R., Lukan, N., Post, S., Schwarzbach, M. H., Willeke, F."Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer". Oncology Reports 16.4 (2006): 657-661.
Chicago
Staiger, W. I., Coy, J. F., Grobholz, R., Hofheinz, R., Lukan, N., Post, S., Schwarzbach, M. H., Willeke, F."Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer". Oncology Reports 16, no. 4 (2006): 657-661. https://doi.org/10.3892/or.16.4.657