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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2006 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Comparison of CD44 expression in primary tumours and metastases of colorectal cancer

  • Authors:
    • R. Bendardaf
    • A. Algars
    • A. Elzagheid
    • E. Korkeila
    • R. Ristamäki
    • H. Lamlum
    • Y. Collan
    • K. Syrjänen
    • S. Pyrhönen

  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland. riyben@utu.fi
  • Pages: 741-746
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/or.16.4.741
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Abstract

A better understanding on the development of a metastatic phenotype in colorectal cancer (CRC) is essential to help identify patients at high risk for metastasis. Therefore, we have studied the role of the CD44 family of trans-membrane glycoprotein in the process of CRC metastasis, by examining the expression of CD44s and CD44v6 in primary tumours and their metastatic lesions in 46 patients using immunohistochemistry. The expression of both CD44s and CD44v6 was significantly higher (moderate/strong) in primary tumours as compared to their metastases (p=0.008, p=0.0001, respectively). CD44s expression in metastases increased with the degree of the histological grade (p=0.009) and invasiveness of the primary tumour (p=0.002). Disease-free survival (DFS) was shorter in patients who had metastases with a strong/moderate expression of CD44s as compared to those with negative/weak expression (8.3 months vs 16.9 months p=0.221, respectively). Our finding that CD44s expression in metastatic lesions may reflect the aggressiveness of the primary tumour from which it has originated implicates an important link between the two lesions. CD44 expression may also provide valuable biological information as suggested by the observation that up-regulated CD44s expression in metastases is associated with a shorter DFS.

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Copy and paste a formatted citation
Spandidos Publications style
Bendardaf R, Algars A, Elzagheid A, Korkeila E, Ristamäki R, Lamlum H, Collan Y, Syrjänen K and Pyrhönen S: Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncol Rep 16: 741-746, 2006.
APA
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H. ... Pyrhönen, S. (2006). Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncology Reports, 16, 741-746. https://doi.org/10.3892/or.16.4.741
MLA
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H., Collan, Y., Syrjänen, K., Pyrhönen, S."Comparison of CD44 expression in primary tumours and metastases of colorectal cancer". Oncology Reports 16.4 (2006): 741-746.
Chicago
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H., Collan, Y., Syrjänen, K., Pyrhönen, S."Comparison of CD44 expression in primary tumours and metastases of colorectal cancer". Oncology Reports 16, no. 4 (2006): 741-746. https://doi.org/10.3892/or.16.4.741
Copy and paste a formatted citation
x
Spandidos Publications style
Bendardaf R, Algars A, Elzagheid A, Korkeila E, Ristamäki R, Lamlum H, Collan Y, Syrjänen K and Pyrhönen S: Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncol Rep 16: 741-746, 2006.
APA
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H. ... Pyrhönen, S. (2006). Comparison of CD44 expression in primary tumours and metastases of colorectal cancer. Oncology Reports, 16, 741-746. https://doi.org/10.3892/or.16.4.741
MLA
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H., Collan, Y., Syrjänen, K., Pyrhönen, S."Comparison of CD44 expression in primary tumours and metastases of colorectal cancer". Oncology Reports 16.4 (2006): 741-746.
Chicago
Bendardaf, R., Algars, A., Elzagheid, A., Korkeila, E., Ristamäki, R., Lamlum, H., Collan, Y., Syrjänen, K., Pyrhönen, S."Comparison of CD44 expression in primary tumours and metastases of colorectal cancer". Oncology Reports 16, no. 4 (2006): 741-746. https://doi.org/10.3892/or.16.4.741
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