Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study

  • Authors:
    • H. Barton Grossman
    • Catherine M. Tangen
    • Carlos Cordon-Cardo
    • Richard Cote
    • Frederic M. Waldman
    • Ralph W. De Vere White
    • Anand B. Karnad
    • Michael Glode
    • E. David Crawford
  • View Affiliations

  • Published online on: October 1, 2006     https://doi.org/10.3892/or.16.4.807
  • Pages: 807-810
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Abstract

In this prospective biomarker study, we evaluated the prognostic significance of Ki67, p53 and angiogenesis in patients with locally advanced bladder cancer. The patients were volunteers from a Southwest Oncology Group trial of locally advanced bladder cancer who were randomized to treatment with neoadjuvant chemotherapy plus cystectomy or cystectomy alone. Tissue specimens were obtained prior to neoadjuvant chemotherapy from 42 patients randomized to receive the combination-treatment arm and 52 randomized to cystectomy alone. The statistical power of the study was quite limited by the small sample size. The biomarkers were assayed by immunohistochemistry. Angiogenesis was determined using anti-CD34 immunostaining. Patients whose tumors had increased Ki67 expression had better progression-free survival that was marginally significant, p=0.063. The median survival in those with higher Ki67 expression was 73 months, and in those with lower expression was 38 months. However, this did not achieve statistical significance, p=0.25. There was a suggestion of worse survival among patients whose tumors exhibited altered p53 staining [hazard ratio (HR) = 1.48; p=0.15], but there was no difference in progression-free survival (HR=1.02; p=0.93). The enumeration of tumor microvessels did not provide prognostic information.

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October 2006
Volume 16 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Grossman HB, Tangen CM, Cordon-Cardo C, Cote R, Waldman FM, De Vere White RW, Karnad AB, Glode M and Crawford ED: Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncol Rep 16: 807-810, 2006
APA
Grossman, H.B., Tangen, C.M., Cordon-Cardo, C., Cote, R., Waldman, F.M., De Vere White, R.W. ... Crawford, E.D. (2006). Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncology Reports, 16, 807-810. https://doi.org/10.3892/or.16.4.807
MLA
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16.4 (2006): 807-810.
Chicago
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16, no. 4 (2006): 807-810. https://doi.org/10.3892/or.16.4.807