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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2006 Volume 16 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study

  • Authors:
    • H. Barton Grossman
    • Catherine M. Tangen
    • Carlos Cordon-Cardo
    • Richard Cote
    • Frederic M. Waldman
    • Ralph W. De Vere White
    • Anand B. Karnad
    • Michael Glode
    • E. David Crawford

  • View Affiliations / Copyright

    Affiliations: The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. hbgrossman@mdanderson.org
  • Pages: 807-810
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/or.16.4.807
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Abstract

In this prospective biomarker study, we evaluated the prognostic significance of Ki67, p53 and angiogenesis in patients with locally advanced bladder cancer. The patients were volunteers from a Southwest Oncology Group trial of locally advanced bladder cancer who were randomized to treatment with neoadjuvant chemotherapy plus cystectomy or cystectomy alone. Tissue specimens were obtained prior to neoadjuvant chemotherapy from 42 patients randomized to receive the combination-treatment arm and 52 randomized to cystectomy alone. The statistical power of the study was quite limited by the small sample size. The biomarkers were assayed by immunohistochemistry. Angiogenesis was determined using anti-CD34 immunostaining. Patients whose tumors had increased Ki67 expression had better progression-free survival that was marginally significant, p=0.063. The median survival in those with higher Ki67 expression was 73 months, and in those with lower expression was 38 months. However, this did not achieve statistical significance, p=0.25. There was a suggestion of worse survival among patients whose tumors exhibited altered p53 staining [hazard ratio (HR) = 1.48; p=0.15], but there was no difference in progression-free survival (HR=1.02; p=0.93). The enumeration of tumor microvessels did not provide prognostic information.

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Copy and paste a formatted citation
Spandidos Publications style
Grossman HB, Tangen CM, Cordon-Cardo C, Cote R, Waldman FM, De Vere White RW, Karnad AB, Glode M and Crawford ED: Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncol Rep 16: 807-810, 2006.
APA
Grossman, H.B., Tangen, C.M., Cordon-Cardo, C., Cote, R., Waldman, F.M., De Vere White, R.W. ... Crawford, E.D. (2006). Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncology Reports, 16, 807-810. https://doi.org/10.3892/or.16.4.807
MLA
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16.4 (2006): 807-810.
Chicago
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16, no. 4 (2006): 807-810. https://doi.org/10.3892/or.16.4.807
Copy and paste a formatted citation
x
Spandidos Publications style
Grossman HB, Tangen CM, Cordon-Cardo C, Cote R, Waldman FM, De Vere White RW, Karnad AB, Glode M and Crawford ED: Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncol Rep 16: 807-810, 2006.
APA
Grossman, H.B., Tangen, C.M., Cordon-Cardo, C., Cote, R., Waldman, F.M., De Vere White, R.W. ... Crawford, E.D. (2006). Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study. Oncology Reports, 16, 807-810. https://doi.org/10.3892/or.16.4.807
MLA
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16.4 (2006): 807-810.
Chicago
Grossman, H. B., Tangen, C. M., Cordon-Cardo, C., Cote, R., Waldman, F. M., De Vere White, R. W., Karnad, A. B., Glode, M., Crawford, E. D."Evaluation of Ki67, p53 and angiogenesis in patients enrolled in a randomized study of neoadjuvant chemotherapy with or without cystectomy: A southwest oncology group study". Oncology Reports 16, no. 4 (2006): 807-810. https://doi.org/10.3892/or.16.4.807
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