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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2006 Volume 16 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 16 Issue 5

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Article

Overexpression of PAX5 in oral carcinogenesis

  • Authors:
    • Sufi Norhany
    • Yukinao Kouzu
    • Katsuhiro Uzawa
    • Masayo Hayama
    • Morihiro Higo
    • Hirofumi Koike
    • Atsushi Kasamatu
    • Hideki Tanzawa

  • View Affiliations / Copyright

    Affiliations: School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 1003-1008
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/or.16.5.1003
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Abstract

The oncogenic transcription factor PAX5 is an important developmental regulator and is implicated in the pathogenesis of several malignancies. The PAX5 gene is involved in medulloblastoma, non-Hodgkin's lymphoma, transitional cell carcinoma of the bladder, neuroblastoma, breast cancer and SCC. In the current study, to determine the potential involvement of PAX5 in oral squamous-cell carcinoma (OSCC) and leukoplakias, we evaluated the status of PAX5 mRNA and protein expression in OSCC cell lines, human primary OSCCs, and leukoplakias by real-time quantitative reverse transcriptase-polymerase chain reaction, Western blot analysis, and immunohistochemistry. A significant increase in PAX5 expression was observed in all OSCC-derived cell lines examined compared to human normal oral keratinocytes (HNOKs). In immunohistochemistry, 78% of tumors and 42% of leukoplakias examined were positive for PAX5, while no immunoreaction was observed in corresponding normal tissues. The results suggest that PAX5 plays an important role during oral carcinogenesis, especially in the early stage, and that the gene may have potential as a biomarker and therapeutic target for OSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Norhany S, Kouzu Y, Uzawa K, Hayama M, Higo M, Koike H, Kasamatu A and Tanzawa H: Overexpression of PAX5 in oral carcinogenesis. Oncol Rep 16: 1003-1008, 2006.
APA
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H. ... Tanzawa, H. (2006). Overexpression of PAX5 in oral carcinogenesis. Oncology Reports, 16, 1003-1008. https://doi.org/10.3892/or.16.5.1003
MLA
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H., Kasamatu, A., Tanzawa, H."Overexpression of PAX5 in oral carcinogenesis". Oncology Reports 16.5 (2006): 1003-1008.
Chicago
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H., Kasamatu, A., Tanzawa, H."Overexpression of PAX5 in oral carcinogenesis". Oncology Reports 16, no. 5 (2006): 1003-1008. https://doi.org/10.3892/or.16.5.1003
Copy and paste a formatted citation
x
Spandidos Publications style
Norhany S, Kouzu Y, Uzawa K, Hayama M, Higo M, Koike H, Kasamatu A and Tanzawa H: Overexpression of PAX5 in oral carcinogenesis. Oncol Rep 16: 1003-1008, 2006.
APA
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H. ... Tanzawa, H. (2006). Overexpression of PAX5 in oral carcinogenesis. Oncology Reports, 16, 1003-1008. https://doi.org/10.3892/or.16.5.1003
MLA
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H., Kasamatu, A., Tanzawa, H."Overexpression of PAX5 in oral carcinogenesis". Oncology Reports 16.5 (2006): 1003-1008.
Chicago
Norhany, S., Kouzu, Y., Uzawa, K., Hayama, M., Higo, M., Koike, H., Kasamatu, A., Tanzawa, H."Overexpression of PAX5 in oral carcinogenesis". Oncology Reports 16, no. 5 (2006): 1003-1008. https://doi.org/10.3892/or.16.5.1003
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