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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2006 Volume 16 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations

  • Authors:
    • Andrzej Semczuk
    • Anna Lorenc
    • Lechoslaw Putowski
    • Konrad Futyma
    • Jaroslaw Bryk
    • Pawel Miotla
    • Ewa Bartnik

  • View Affiliations / Copyright

    Affiliations: Second Department of Gynecology, Lublin University School of Medicine, 20-954 Lublin, Poland. andrzej.semczuk@am.lublin.pl
  • Pages: 1041-1045
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/or.16.5.1041
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Abstract

Somatic mitochondrial DNA (mtDNA) mutations have been found in a subset of endometrial cancers (EC) from different populations. We have investigated the relationship between mtDNA changes and clinical and pathological variables of women affected by EC. mtDNA mutations were detected both in early (3/32; 9%) and in advanced (1/8; 12%) stages of uterine tumors. However, patients carrying the mtDNA mutations or the normal mtDNA sequence had indistinguishable clinicopathological data, including age, clinical stage, histological grade and type or depth of myometrial invasion. It is noteworthy that mtDNA mutations were not detected in hyperplastic endometrial tissues or in ECs coexisting with hyperplasia, nor in a single case of endometrial stromal sarcoma. LOH at the tumor suppressor genes RB1 and TP53 as well as p16INK4A alterations (LOH, gene deletion) were found in tumors carrying mtDNA mutations. These results suggest that somatic mtDNA mutations are detected in a subset of ECs, although they are unrelated to clinicopathological variables of cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Semczuk A, Lorenc A, Putowski L, Futyma K, Bryk J, Miotla P and Bartnik E: Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations. Oncol Rep 16: 1041-1045, 2006.
APA
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., & Bartnik, E. (2006). Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations. Oncology Reports, 16, 1041-1045. https://doi.org/10.3892/or.16.5.1041
MLA
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., Bartnik, E."Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations". Oncology Reports 16.5 (2006): 1041-1045.
Chicago
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., Bartnik, E."Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations". Oncology Reports 16, no. 5 (2006): 1041-1045. https://doi.org/10.3892/or.16.5.1041
Copy and paste a formatted citation
x
Spandidos Publications style
Semczuk A, Lorenc A, Putowski L, Futyma K, Bryk J, Miotla P and Bartnik E: Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations. Oncol Rep 16: 1041-1045, 2006.
APA
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., & Bartnik, E. (2006). Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations. Oncology Reports, 16, 1041-1045. https://doi.org/10.3892/or.16.5.1041
MLA
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., Bartnik, E."Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations". Oncology Reports 16.5 (2006): 1041-1045.
Chicago
Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P., Bartnik, E."Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations". Oncology Reports 16, no. 5 (2006): 1041-1045. https://doi.org/10.3892/or.16.5.1041
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