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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2006 Volume 16 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 16 Issue 5

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Article

Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer

  • Authors:
    • Takanori Matsui
    • Kenji Omura
    • Kazuyuki Kawakami
    • Satoshi Morita
    • Junichi Sakamoto

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Research, Aichi Cancer Center Aichi Hospital, Aichi 444-0011, Japan. matsui-ngy@umin.ac.jp
  • Pages: 1111-1115
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/or.16.5.1111
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Abstract

Thymidylate synthase [TS, (EC 2.1.1.45)] is the target enzyme in 5-fluorouracil treatment. Recently, the DNA polymorphism of this gene has been found to affect TS protein (pTS) expression. However, no prospective studies have been performed to evaluate the influence of this polymorphism on the clinical efficacy of 5-FU-based adjuvant chemotherapy for colorectal cancer (CRC). In this study, we investigated the genotype of TS and immunopathological findings of pTS in 161 colon cancer specimens from patients who were registered in a prospective adjuvant immunochemotherapy clinical trial. The clinical course and prognosis of these patients were checked after the study had been completed. This study comprised 11 (6.8%) cases of 2R/2R, 40 (24.8%) of 2R/3R, and 110 (68.3%) of 3R/3R genotypes. All of the 2R/2R cases were still alive at the time of analysis although this finding was not statistically significant. In this prospective examination on a randomized controlled trial, the patients with colon cancer of the 2R/2R TS genotype may be good responders to 5-FU-based adjuvant chemotherapy. Furthermore, differences in the proportions of the TS genotypes can account for the interracial differences in the adverse effects of 5-FU-based chemotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Matsui T, Omura K, Kawakami K, Morita S and Sakamoto J: Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncol Rep 16: 1111-1115, 2006.
APA
Matsui, T., Omura, K., Kawakami, K., Morita, S., & Sakamoto, J. (2006). Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncology Reports, 16, 1111-1115. https://doi.org/10.3892/or.16.5.1111
MLA
Matsui, T., Omura, K., Kawakami, K., Morita, S., Sakamoto, J."Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer". Oncology Reports 16.5 (2006): 1111-1115.
Chicago
Matsui, T., Omura, K., Kawakami, K., Morita, S., Sakamoto, J."Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer". Oncology Reports 16, no. 5 (2006): 1111-1115. https://doi.org/10.3892/or.16.5.1111
Copy and paste a formatted citation
x
Spandidos Publications style
Matsui T, Omura K, Kawakami K, Morita S and Sakamoto J: Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncol Rep 16: 1111-1115, 2006.
APA
Matsui, T., Omura, K., Kawakami, K., Morita, S., & Sakamoto, J. (2006). Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer. Oncology Reports, 16, 1111-1115. https://doi.org/10.3892/or.16.5.1111
MLA
Matsui, T., Omura, K., Kawakami, K., Morita, S., Sakamoto, J."Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer". Oncology Reports 16.5 (2006): 1111-1115.
Chicago
Matsui, T., Omura, K., Kawakami, K., Morita, S., Sakamoto, J."Genotype of thymidylate synthase likely to affect efficacy of adjuvant 5-FU based chemotherapy in colon cancer". Oncology Reports 16, no. 5 (2006): 1111-1115. https://doi.org/10.3892/or.16.5.1111
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