Dose effect of soy supplementation in prostate cancer: A pilot study

  • Authors:
    • Peter J. van Veldhuizen
    • J. Brantley Thrasher
    • Gibanananda Ray
    • Rachel Cherian
    • Jan Ward
    • Jeffrey Holzbeierlein
    • Stefan Gutow
    • Sushanta K. Banerjee
  • View Affiliations

  • Published online on: December 1, 2006     https://doi.org/10.3892/or.16.6.1221
  • Pages: 1221-1224
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Abstract

We performed a pilot study to determine the dose effect of soy supplement on serum hormonal levels, estrogen receptor α (ERα) and androgen receptor (AR) expression in patients scheduled to undergo prostatectomy. Cohorts of 3-4 eligible patients received escalating doses of a commercial soy supplement, Flav-ein, from the time of study enrollment until prostatectomy. Serum levels of prostate specific antigen (PSA), testosterone, and estrogen were measured at study enrollment and prior to prostatectomy. AR and ERα expression was evaluated in the pretreatment biopsy specimen and post-treatment prostatectomy specimen using immunohistochemical analysis. A total of 13 patients were enrolled in this pilot study and 11 patients were assessable for response. With soy supplementation, serum testosterone levels decreased in 9 of 11 patients and estrogen levels decreased in 8 of 10 patients in a dose-dependent manner. There was a variable effect on ERα expression with downregulation of receptor expression seen at the highest dose level. There was no effect on AR expression. In conclusion, supplementation with this commercial soy product produced a consistent decrease in serum sex hormone levels. Additional studies are needed to evaluate a potential dose effect on ERα expression.

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December 2006
Volume 16 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
van Veldhuizen PJ, Thrasher JB, Ray G, Cherian R, Ward J, Holzbeierlein J, Gutow S and Banerjee SK: Dose effect of soy supplementation in prostate cancer: A pilot study. Oncol Rep 16: 1221-1224, 2006
APA
van Veldhuizen, P.J., Thrasher, J.B., Ray, G., Cherian, R., Ward, J., Holzbeierlein, J. ... Banerjee, S.K. (2006). Dose effect of soy supplementation in prostate cancer: A pilot study. Oncology Reports, 16, 1221-1224. https://doi.org/10.3892/or.16.6.1221
MLA
van Veldhuizen, P. J., Thrasher, J. B., Ray, G., Cherian, R., Ward, J., Holzbeierlein, J., Gutow, S., Banerjee, S. K."Dose effect of soy supplementation in prostate cancer: A pilot study". Oncology Reports 16.6 (2006): 1221-1224.
Chicago
van Veldhuizen, P. J., Thrasher, J. B., Ray, G., Cherian, R., Ward, J., Holzbeierlein, J., Gutow, S., Banerjee, S. K."Dose effect of soy supplementation in prostate cancer: A pilot study". Oncology Reports 16, no. 6 (2006): 1221-1224. https://doi.org/10.3892/or.16.6.1221