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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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December 2006 Volume 16 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2006 Volume 16 Issue 6

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Article

The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines

  • Authors:
    • Tatsuo Shimura
    • Taketoshi Suehiro
    • Hideki Suzuki
    • Koji Okada
    • Kenichiro Araki
    • Takayuki Asao
    • Hiroyuki Kuwano
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma 371-8511, Japan
  • Pages: 1375-1380
    |
    Published online on: December 1, 2006
       https://doi.org/10.3892/or.16.6.1375
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Abstract

A soluble form of human leukocyte antigen class I antigen (sHLA-I) has been reported to cause apoptosis on cytotoxic T cells and inhibit killer activity of natural killer cells via killer-cell inhibitory receptors. However, its effect on cancer cells has not yet been elucidated. We examined the direct effect of sHLA-I on human liver cancer cell lines, HepG2, HLE and HLF. The effects of sHLA-I on cell growth, DNA synthesis, and apoptosis induction were evaluated. To elucidate the mechanisms, cDNA expression arrays were also examined. sHLA-I caused cell growth inhibition, resulting in apoptosis on human hepatocellular carcinoma, dose-dependently. In this process, caspase-3 was activated. sHLA-I also inhibited in vivo growth of hepatocellular carcinoma in severe combined immunodeficient mice. sHLA-I caused apoptosis on human hepatocellular carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Asao T and Kuwano H: The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines. Oncol Rep 16: 1375-1380, 2006.
APA
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., & Kuwano, H. (2006). The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines. Oncology Reports, 16, 1375-1380. https://doi.org/10.3892/or.16.6.1375
MLA
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., Kuwano, H."The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines". Oncology Reports 16.6 (2006): 1375-1380.
Chicago
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., Kuwano, H."The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines". Oncology Reports 16, no. 6 (2006): 1375-1380. https://doi.org/10.3892/or.16.6.1375
Copy and paste a formatted citation
x
Spandidos Publications style
Shimura T, Suehiro T, Suzuki H, Okada K, Araki K, Asao T and Kuwano H: The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines. Oncol Rep 16: 1375-1380, 2006.
APA
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., & Kuwano, H. (2006). The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines. Oncology Reports, 16, 1375-1380. https://doi.org/10.3892/or.16.6.1375
MLA
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., Kuwano, H."The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines". Oncology Reports 16.6 (2006): 1375-1380.
Chicago
Shimura, T., Suehiro, T., Suzuki, H., Okada, K., Araki, K., Asao, T., Kuwano, H."The soluble form of human leukocyte antigen class I antigen causes apoptosis on hepatocellular carcinoma cell lines". Oncology Reports 16, no. 6 (2006): 1375-1380. https://doi.org/10.3892/or.16.6.1375
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