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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2007 Volume 17 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate

  • Authors:
    • Takuhiro Uto
    • Makoto Fujii
    • De-Xing Hou

  • View Affiliations / Copyright

    Affiliations: Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Kagoshima City 890-0065, Japan
  • Pages: 233-238
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/or.17.1.233
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Abstract

6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) is a bioactive compound extracted from a typical Japanese spice, wasabi (Wasabia japonica (Miq.) Matsumura). In the present study, we found that 6-MITC suppressed the expression of cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS), interferon-γ (IFN-γ), but did not suppress that induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), in murine macrophage RAW264. Molecular mechanisms were investigated by targeting the transcriptional factors including activator protein-1 (AP-1), CCAAT/enhancer-binding protein δ (C/EBPδ), CRE-binding protein (CREB) and nuclear factor κB (NF-κB), which bind to the core element of COX-2 promoter. LPS induced activation of all of these factors and 6-MITC suppressed LPS-induced activation of AP-1, C/EBPδ, CREB, but not NF-κB. IFN-γ did not induce any activation of these factors, but 6-MITC suppressed IFN-γ-induced COX-2 expression, suggesting that the upstream region of the core element is linked for this suppression. Finally, TPA stimulated the activation of CREB and AP-1, but 6-MITC did not block TPA-induced COX-2 expression. These results suggest that LPS, IFN-γ and TPA regulate COX-2 expression through different mechanisms, and 6-MITC acts as a potent inhibitor of COX-2 expression induced by LPS or IFN-γ.

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Copy and paste a formatted citation
Spandidos Publications style
Uto T, Fujii M and Hou D: Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate. Oncol Rep 17: 233-238, 2007.
APA
Uto, T., Fujii, M., & Hou, D. (2007). Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate. Oncology Reports, 17, 233-238. https://doi.org/10.3892/or.17.1.233
MLA
Uto, T., Fujii, M., Hou, D."Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate". Oncology Reports 17.1 (2007): 233-238.
Chicago
Uto, T., Fujii, M., Hou, D."Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate". Oncology Reports 17, no. 1 (2007): 233-238. https://doi.org/10.3892/or.17.1.233
Copy and paste a formatted citation
x
Spandidos Publications style
Uto T, Fujii M and Hou D: Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate. Oncol Rep 17: 233-238, 2007.
APA
Uto, T., Fujii, M., & Hou, D. (2007). Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate. Oncology Reports, 17, 233-238. https://doi.org/10.3892/or.17.1.233
MLA
Uto, T., Fujii, M., Hou, D."Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate". Oncology Reports 17.1 (2007): 233-238.
Chicago
Uto, T., Fujii, M., Hou, D."Effects of 6-(methylsulfinyl)hexyl isothiocyanate on cyclooxygenase-2 expression induced by lipopolysaccharide, interferon-γ and 12-O-tetradecanoylphorbol-13-acetate". Oncology Reports 17, no. 1 (2007): 233-238. https://doi.org/10.3892/or.17.1.233
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