Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma

  • Authors:
    • Y. T. Yeh
    • F. Ou-Yang
    • I. F. Chen
    • S. F. Yang
    • J. H. Su
    • M. F. Hou
    • S. S. Yuan
  • View Affiliations

  • Published online on: January 1, 2007     https://doi.org/10.3892/or.17.1.35
  • Pages: 35-39
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Abstract

The mammalian Janus kinase (JAK) family consists of four members, namely JAK1, JAK2, JAK3 and TYK2, which play a critical role in cytokine/growth factor signaling and is increasingly associated with human cancers. Aberrant activation of these non-receptor tyrosine kinases may contribute to carcinogenesis. Herein, we focused on exploring the potential role of p-JAK1 in breast cancer. The expression profiles of p-JAK1 were analyzed in 68 pairs of cancer and non-cancer breast tissues from the same infiltrating ductal carcinoma case by using immunoblotting technique. The results obtained were further correlated with clinicopathological characteristics. Intriguingly, p-JAK1 expression was decreased in 55.9% of breast cancer tissues as compared to the matched non-cancer tissues. Further immunohistochemistry study showed an intense p-JAK1 staining predominantly in adjacent normal breast tissues but not the matched cancer lesions. Decreased p-JAK1 expression in breast cancer tissues was significantly correlated with positive estrogen receptor (ER) status and increased tumor size (p=0.010 and 0.009). We also found that p-JAK1 expression was high in ERα-negative breast cancer cell lines but was low in ERα-positive breast cell lines. Transfection of ERα-positive MCF-7 cells with an ERα-specific siRNA upregulated the expression of p-JAK1. In summary, our results indicated that an altered p-JAK1 expression might be involved in the development of breast infiltrating ductal carcinoma in an ERα-related manner.

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January 2007
Volume 17 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yeh YT, Ou-Yang F, Chen IF, Yang SF, Su JH, Hou MF and Yuan SS: Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma. Oncol Rep 17: 35-39, 2007
APA
Yeh, Y.T., Ou-Yang, F., Chen, I.F., Yang, S.F., Su, J.H., Hou, M.F., & Yuan, S.S. (2007). Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma. Oncology Reports, 17, 35-39. https://doi.org/10.3892/or.17.1.35
MLA
Yeh, Y. T., Ou-Yang, F., Chen, I. F., Yang, S. F., Su, J. H., Hou, M. F., Yuan, S. S."Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma". Oncology Reports 17.1 (2007): 35-39.
Chicago
Yeh, Y. T., Ou-Yang, F., Chen, I. F., Yang, S. F., Su, J. H., Hou, M. F., Yuan, S. S."Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma". Oncology Reports 17, no. 1 (2007): 35-39. https://doi.org/10.3892/or.17.1.35