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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 17 Issue 2

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Article

Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis

  • Authors:
    • Edwin Herrmann
    • Elke Eltze
    • Stefan Bierer
    • Martin Bogemann
    • Olaf Anselm Brinkmann
    • Hoda Balnowair
    • Lothar Hertle
    • Christian Wulfing

  • View Affiliations / Copyright

    Affiliations: Department of Urology, University of Münster, 48149 Münster, Germany. herrmae@ukmuenster.de
  • Pages: 275-280
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.275
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Abstract

Endothelin-1 and its receptors ETAR and ETBR, commonly referred to as the Endothelin-axis, are emerging to play a role in cancer. The Endothelin-axis has been shown to be involved in proliferation, angiogenesis and metastasis in various human tumours. To assess the role of the Endothelin-axis in renal cell carcinoma, we analysed its expression in archival tumour tissue of 183 patients. Representative tumour blocks were selected for constructing a tissue microarray. Paraffin sections were assessed immunohistochemically using monoclonal and polyclonal antibodies for Endothelin-1, ETAR and ETBR. Staining intensities were analysed semiquantitatively and the results were correlated with various histopathologic factors. Overexpression of Endothelin-1, ETAR and ETBR was identified in 12.8%, 84.1% and 93.3% of cases, respectively. No association with pathological tumour stage and histologic grading was found. Papillary renal cell carcinomas expressed highly significantly more Endothelin-1 than clear cell renal cell carcinomas (34.5% vs. 6.7%, p<0.001), while there was no difference between ETAR- and ETBR-expression in these histologic subtypes. However, ETAR tended to be overexpressed in the subgroup of G3-tumours (p=0.044). Studies are underway assessing the role of the Endothelin-axis and its potential use as a molecular target in renal cell carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Herrmann E, Eltze E, Bierer S, Bogemann M, Brinkmann OA, Balnowair H, Hertle L and Wulfing C: Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncol Rep 17: 275-280, 2007.
APA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O.A., Balnowair, H. ... Wulfing, C. (2007). Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncology Reports, 17, 275-280. https://doi.org/10.3892/or.17.2.275
MLA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17.2 (2007): 275-280.
Chicago
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17, no. 2 (2007): 275-280. https://doi.org/10.3892/or.17.2.275
Copy and paste a formatted citation
x
Spandidos Publications style
Herrmann E, Eltze E, Bierer S, Bogemann M, Brinkmann OA, Balnowair H, Hertle L and Wulfing C: Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncol Rep 17: 275-280, 2007.
APA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O.A., Balnowair, H. ... Wulfing, C. (2007). Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncology Reports, 17, 275-280. https://doi.org/10.3892/or.17.2.275
MLA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17.2 (2007): 275-280.
Chicago
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17, no. 2 (2007): 275-280. https://doi.org/10.3892/or.17.2.275
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