Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis

  • Authors:
    • Edwin Herrmann
    • Elke Eltze
    • Stefan Bierer
    • Martin Bogemann
    • Olaf Anselm Brinkmann
    • Hoda Balnowair
    • Lothar Hertle
    • Christian Wulfing
  • View Affiliations

  • Published online on: February 1, 2007     https://doi.org/10.3892/or.17.2.275
  • Pages: 275-280
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Abstract

Endothelin-1 and its receptors ETAR and ETBR, commonly referred to as the Endothelin-axis, are emerging to play a role in cancer. The Endothelin-axis has been shown to be involved in proliferation, angiogenesis and metastasis in various human tumours. To assess the role of the Endothelin-axis in renal cell carcinoma, we analysed its expression in archival tumour tissue of 183 patients. Representative tumour blocks were selected for constructing a tissue microarray. Paraffin sections were assessed immunohistochemically using monoclonal and polyclonal antibodies for Endothelin-1, ETAR and ETBR. Staining intensities were analysed semiquantitatively and the results were correlated with various histopathologic factors. Overexpression of Endothelin-1, ETAR and ETBR was identified in 12.8%, 84.1% and 93.3% of cases, respectively. No association with pathological tumour stage and histologic grading was found. Papillary renal cell carcinomas expressed highly significantly more Endothelin-1 than clear cell renal cell carcinomas (34.5% vs. 6.7%, p<0.001), while there was no difference between ETAR- and ETBR-expression in these histologic subtypes. However, ETAR tended to be overexpressed in the subgroup of G3-tumours (p=0.044). Studies are underway assessing the role of the Endothelin-axis and its potential use as a molecular target in renal cell carcinoma.

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February 2007
Volume 17 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Herrmann E, Eltze E, Bierer S, Bogemann M, Brinkmann OA, Balnowair H, Hertle L and Wulfing C: Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncol Rep 17: 275-280, 2007
APA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O.A., Balnowair, H. ... Wulfing, C. (2007). Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis. Oncology Reports, 17, 275-280. https://doi.org/10.3892/or.17.2.275
MLA
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17.2 (2007): 275-280.
Chicago
Herrmann, E., Eltze, E., Bierer, S., Bogemann, M., Brinkmann, O. A., Balnowair, H., Hertle, L., Wulfing, C."Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis". Oncology Reports 17, no. 2 (2007): 275-280. https://doi.org/10.3892/or.17.2.275