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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 17 Issue 2

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Article

Antitumor effects of ZD6474 on head and neck squamous cell carcinoma

  • Authors:
    • Daisuke Sano
    • Mariko Kawakami
    • Kyoko Fujita
    • Machiko Kimura
    • Yukiko Yamashita
    • Yukari Ishiguro
    • Goshi Nishimura
    • Hideki Matsuda
    • Mamoru Tsukuda

  • View Affiliations / Copyright

    Affiliations: Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. t046028d@yokohama-cu.ac.jp
  • Pages: 289-295
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.289
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Abstract

Angiogenesis is required for tumor growth and metastasis and, therefore, represents a target for cancer treatment. While many factors have been implicated in promoting angiogenesis, vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. ZD6474 is a potent VEGF receptor-2 (VEGFR-2) tyrosine kinase inhibitor which also has activity against the epidermal growth factor receptor (EGFR) tyrosine kinase. The purpose of this study was to investigate the sensitivity of head and neck squamous cell carcinoma (HNSCC) cell lines to ZD6474, and to evaluate its antitumor efficacy on HNSCC xenografts. This is the first demonstration of antitumor effects of ZD6474 on HNSCC. In vitro ZD6474 displayed antiproliferative effects on HNSCC cells and inhibition of VEGFR-2 and EGFR pathways. In vivo ZD6474 displayed antitumor activity, induced apoptosis and antiangiogenic activity on nude mice bearing an established xenograft of YCU-H891 cells. These results suggest that ZD6474 has the potential to inhibit two key pathways in tumor growth via inhibition of VEGF-dependent tumor angiogenesis and via inhibition of EGFR-dependent tumor cell proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
Sano D, Kawakami M, Fujita K, Kimura M, Yamashita Y, Ishiguro Y, Nishimura G, Matsuda H and Tsukuda M: Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncol Rep 17: 289-295, 2007.
APA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y. ... Tsukuda, M. (2007). Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncology Reports, 17, 289-295. https://doi.org/10.3892/or.17.2.289
MLA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17.2 (2007): 289-295.
Chicago
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17, no. 2 (2007): 289-295. https://doi.org/10.3892/or.17.2.289
Copy and paste a formatted citation
x
Spandidos Publications style
Sano D, Kawakami M, Fujita K, Kimura M, Yamashita Y, Ishiguro Y, Nishimura G, Matsuda H and Tsukuda M: Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncol Rep 17: 289-295, 2007.
APA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y. ... Tsukuda, M. (2007). Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncology Reports, 17, 289-295. https://doi.org/10.3892/or.17.2.289
MLA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17.2 (2007): 289-295.
Chicago
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17, no. 2 (2007): 289-295. https://doi.org/10.3892/or.17.2.289
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