Antitumor effects of ZD6474 on head and neck squamous cell carcinoma

  • Authors:
    • Daisuke Sano
    • Mariko Kawakami
    • Kyoko Fujita
    • Machiko Kimura
    • Yukiko Yamashita
    • Yukari Ishiguro
    • Goshi Nishimura
    • Hideki Matsuda
    • Mamoru Tsukuda
  • View Affiliations

  • Published online on: February 1, 2007     https://doi.org/10.3892/or.17.2.289
  • Pages: 289-295
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Abstract

Angiogenesis is required for tumor growth and metastasis and, therefore, represents a target for cancer treatment. While many factors have been implicated in promoting angiogenesis, vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. ZD6474 is a potent VEGF receptor-2 (VEGFR-2) tyrosine kinase inhibitor which also has activity against the epidermal growth factor receptor (EGFR) tyrosine kinase. The purpose of this study was to investigate the sensitivity of head and neck squamous cell carcinoma (HNSCC) cell lines to ZD6474, and to evaluate its antitumor efficacy on HNSCC xenografts. This is the first demonstration of antitumor effects of ZD6474 on HNSCC. In vitro ZD6474 displayed antiproliferative effects on HNSCC cells and inhibition of VEGFR-2 and EGFR pathways. In vivo ZD6474 displayed antitumor activity, induced apoptosis and antiangiogenic activity on nude mice bearing an established xenograft of YCU-H891 cells. These results suggest that ZD6474 has the potential to inhibit two key pathways in tumor growth via inhibition of VEGF-dependent tumor angiogenesis and via inhibition of EGFR-dependent tumor cell proliferation.

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February 2007
Volume 17 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Sano D, Kawakami M, Fujita K, Kimura M, Yamashita Y, Ishiguro Y, Nishimura G, Matsuda H and Tsukuda M: Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncol Rep 17: 289-295, 2007.
APA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y. ... Tsukuda, M. (2007). Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncology Reports, 17, 289-295. https://doi.org/10.3892/or.17.2.289
MLA
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17.2 (2007): 289-295.
Chicago
Sano, D., Kawakami, M., Fujita, K., Kimura, M., Yamashita, Y., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Antitumor effects of ZD6474 on head and neck squamous cell carcinoma". Oncology Reports 17, no. 2 (2007): 289-295. https://doi.org/10.3892/or.17.2.289