Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis

  • Authors:
    • Shahana Begum
    • Yan Zhang
    • Tomoaki Shintani
    • Shigeaki Toratani
    • J. Denry Sato
    • Tetsuji Okamoto
  • View Affiliations

  • Published online on: March 1, 2007     https://doi.org/10.3892/or.17.3.591
  • Pages: 591-596
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) is a secreted protein that releases immobilized fibroblast growth factor-2 (FGF-2) from the extracellular matrix and plays a critical role in FGF bioactivation. In the present study co-localization of FGF-2 and HBp17/FGFBP-1 was observed in oral tissues including normal mucosa, hyperplasia, dysplasia of different degrees and oral squamous cell carcinoma (OSCC). The expression score for HBp17/FGFBP-1, FGF-2 as well as vascular endothelial growth factor A (VEGF-A) became higher with the severity of epithelial dysplasia and was highest in severe dysplasia. The expression of HBp17/FGFBP-1, FGF-2 and VEGF-A showed significant association with microvessel density, but no correlation with TNM stages or OSCC recurrence interval. Our results demonstrated that HBp17/FGFBP-1, like VEGF-A and FGF-2, might also promote the induction of tumor angiogenesis. The strongest expression of angiogenic factors in severe dysplasia suggests a potential point for targeting novel anti-angiogenic therapeutic strategies.

Related Articles

Journal Cover

March 2007
Volume 17 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Begum S, Zhang Y, Shintani T, Toratani S, Sato JD and Okamoto T: Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis. Oncol Rep 17: 591-596, 2007
APA
Begum, S., Zhang, Y., Shintani, T., Toratani, S., Sato, J.D., & Okamoto, T. (2007). Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis. Oncology Reports, 17, 591-596. https://doi.org/10.3892/or.17.3.591
MLA
Begum, S., Zhang, Y., Shintani, T., Toratani, S., Sato, J. D., Okamoto, T."Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis". Oncology Reports 17.3 (2007): 591-596.
Chicago
Begum, S., Zhang, Y., Shintani, T., Toratani, S., Sato, J. D., Okamoto, T."Immunohistochemical expression of heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) as an angiogenic factor in head and neck tumorigenesis". Oncology Reports 17, no. 3 (2007): 591-596. https://doi.org/10.3892/or.17.3.591