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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2007 Volume 17 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway

  • Authors:
    • Xia Liu
    • Chunjing Bian
    • Kaihuan Ren
    • Haixia Jin
    • Baowei Li
    • Rong-Guang Shao

  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
  • Pages: 597-603
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/or.17.3.597
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Abstract

Lidamycin (LDM), a member of the enediyne antibiotic family, is presently undergoing phase I clinical trials in P.R. China. In this study, we investigated the mechanisms of LDM-induced cell cycle arrest in order to support its use in clinical cancer therapy. Using human colon carcinoma HT-29 cells, we observed that LDM induced G2 cell cycle arrest in a time- and dose-dependent manner. LDM-induced G2 arrest was associated with increasing phosphorylation of Chk1, Chk2, Cdc25C, Cdc2 and expression of Cdc2 and cyclin B1. In addition, cytoplasmic localization of cyclin B1 was also involved in LDM-induced G2 arrest. Moreover, we found that p38 MAPK pathway contributed to LDM-induced G2 arrest. Inhibition of p38 MAPK by its inhibitor SB203580 not only attenuated LDM-induced G2 arrest but also potentiated LDM-induced apoptosis, which was accompanied by decreasing phosphorylation of Cdc2 and increasing expression of FasL and phosphorylation of JNK. Finally, we demonstrated that cells at G1 phase were more sensitive to LDM. Together, our findings suggest that p38 MAPK signaling pathway is involved in LDM-induced G2 arrest, at least partly, and a combination of LDM with p38 MAPK inhibitor may represent a new strategy for human colon cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Bian C, Ren K, Jin H, Li B and Shao R: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncol Rep 17: 597-603, 2007.
APA
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., & Shao, R. (2007). Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncology Reports, 17, 597-603. https://doi.org/10.3892/or.17.3.597
MLA
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., Shao, R."Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway". Oncology Reports 17.3 (2007): 597-603.
Chicago
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., Shao, R."Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway". Oncology Reports 17, no. 3 (2007): 597-603. https://doi.org/10.3892/or.17.3.597
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Bian C, Ren K, Jin H, Li B and Shao R: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncol Rep 17: 597-603, 2007.
APA
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., & Shao, R. (2007). Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. Oncology Reports, 17, 597-603. https://doi.org/10.3892/or.17.3.597
MLA
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., Shao, R."Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway". Oncology Reports 17.3 (2007): 597-603.
Chicago
Liu, X., Bian, C., Ren, K., Jin, H., Li, B., Shao, R."Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway". Oncology Reports 17, no. 3 (2007): 597-603. https://doi.org/10.3892/or.17.3.597
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