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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2007 Volume 17 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide

  • Authors:
    • Olivier Faure
    • Stéphanie Graff-Dubois
    • Pedro M.S. Alves
    • Sébastien Cornet
    • Marie-Thérèse Duffour
    • Antonio Scardino
    • David-Alexandre Gross
    • Isabelle Miconnet
    • Margarita Salcedo
    • Salem Chouaib
    • François A. Lemonnier
    • Jean-Pierre Abastado
    • Kostas Kosmatopoulos
  • View Affiliations / Copyright

    Affiliations: INSERM U487, Institut Gustave Roussy, 94805 Villejuif, France. ofaure@idm-biotech.com
  • Pages: 679-685
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/or.17.3.679
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Abstract

The inducible heat shock protein Hsp70 has been described as a tumour antigen being frequently overexpressed in tumours of various histologic origins, with a role in tumourigenicity, as a critical event in tumour progression. A strategy to enhance the immune response to an antigen is the identification of multiple epitopes and the induction of a polyspecific response. Applied to tumour vaccination, such a polyspecific response should lead to a more robust antitumour efficacy. The long peptide Hsp70380-402 encompasses three nonamer peptides with a high affinity for HLA-A∗0201. In a previous paper, we have shown that two of these nonamer peptides, p391 and p393, can raise CTL to recognize tumour cells overexpressing Hsp70. In the present paper, we demonstrate that the third nonamer peptide, p380, is a new epitope efficient in raising an antitumour immune response. The p380-402 polypeptide was able to induce an immune response against each of the three constituent epitopes both in vivo in HLA-A∗0201 transgenic mice and in vitro with human PBMC. This polypeptide therefore constitutes an interesting candidate for the induction of multiple HLA-A∗0201-restricted anti-Hsp70 antitumour CTL responses.

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Copy and paste a formatted citation
Spandidos Publications style
Faure O, Graff-Dubois S, Alves PM, Cornet S, Duffour M, Scardino A, Gross D, Miconnet I, Salcedo M, Chouaib S, Chouaib S, et al: Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Oncol Rep 17: 679-685, 2007.
APA
Faure, O., Graff-Dubois, S., Alves, P.M., Cornet, S., Duffour, M., Scardino, A. ... Kosmatopoulos, K. (2007). Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Oncology Reports, 17, 679-685. https://doi.org/10.3892/or.17.3.679
MLA
Faure, O., Graff-Dubois, S., Alves, P. M., Cornet, S., Duffour, M., Scardino, A., Gross, D., Miconnet, I., Salcedo, M., Chouaib, S., Lemonnier, F. A., Abastado, J., Kosmatopoulos, K."Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide". Oncology Reports 17.3 (2007): 679-685.
Chicago
Faure, O., Graff-Dubois, S., Alves, P. M., Cornet, S., Duffour, M., Scardino, A., Gross, D., Miconnet, I., Salcedo, M., Chouaib, S., Lemonnier, F. A., Abastado, J., Kosmatopoulos, K."Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide". Oncology Reports 17, no. 3 (2007): 679-685. https://doi.org/10.3892/or.17.3.679
Copy and paste a formatted citation
x
Spandidos Publications style
Faure O, Graff-Dubois S, Alves PM, Cornet S, Duffour M, Scardino A, Gross D, Miconnet I, Salcedo M, Chouaib S, Chouaib S, et al: Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Oncol Rep 17: 679-685, 2007.
APA
Faure, O., Graff-Dubois, S., Alves, P.M., Cornet, S., Duffour, M., Scardino, A. ... Kosmatopoulos, K. (2007). Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide. Oncology Reports, 17, 679-685. https://doi.org/10.3892/or.17.3.679
MLA
Faure, O., Graff-Dubois, S., Alves, P. M., Cornet, S., Duffour, M., Scardino, A., Gross, D., Miconnet, I., Salcedo, M., Chouaib, S., Lemonnier, F. A., Abastado, J., Kosmatopoulos, K."Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide". Oncology Reports 17.3 (2007): 679-685.
Chicago
Faure, O., Graff-Dubois, S., Alves, P. M., Cornet, S., Duffour, M., Scardino, A., Gross, D., Miconnet, I., Salcedo, M., Chouaib, S., Lemonnier, F. A., Abastado, J., Kosmatopoulos, K."Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide". Oncology Reports 17, no. 3 (2007): 679-685. https://doi.org/10.3892/or.17.3.679
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