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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2007 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 17 Issue 5

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Article

Gene profile analysis of colorectal cancer cell lines by cDNA macroarray

  • Authors:
    • Noboru Saito
    • Shingo Kameoka
    • Ryuji Furukawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Tokyo Women's Medical University School of Medicine, Tokyo 162-8666, Japan. nobosaito@surg2.twmu.ac.jp
  • Pages: 1061-1065
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/or.17.5.1061
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Abstract

In order to identify high-risk groups of patients with cancer, understanding the mechanisms of invasion and metastasis from the viewpoint of gene expression is required; in particular, the changes in gene expression as tumours gain the ability to metastasise. Using a rat model of metastatic colorectal cancer (CRC), we determined the expression profiles of CRC cells that metastasised to the liver and the lung. In the hepatopulmonary metastasis model, metastasising ability increased with successive transplanted cell line generations. No significant differences in cellular proliferation ability were seen between the original cell line and succeeding metastatic cell lines. Analysis using cDNA macroarray showed that metastasising ability was associated with increased expression of integrin β4, γ-catenin, Smad 7, Bax, Bcl-2, c-fos and TGF-α, and a particularly marked increased expression of TGF-β, PDGFb, Cdk4 and Rho B. Expression of both Rho GDIβ and Gelsolin was reduced. These results suggest that high metastasising ability does not derive from a single gene, but rather through accumulated changes in the expression of several different genes.

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Copy and paste a formatted citation
Spandidos Publications style
Saito N, Kameoka S and Furukawa R: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncol Rep 17: 1061-1065, 2007.
APA
Saito, N., Kameoka, S., & Furukawa, R. (2007). Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncology Reports, 17, 1061-1065. https://doi.org/10.3892/or.17.5.1061
MLA
Saito, N., Kameoka, S., Furukawa, R."Gene profile analysis of colorectal cancer cell lines by cDNA macroarray". Oncology Reports 17.5 (2007): 1061-1065.
Chicago
Saito, N., Kameoka, S., Furukawa, R."Gene profile analysis of colorectal cancer cell lines by cDNA macroarray". Oncology Reports 17, no. 5 (2007): 1061-1065. https://doi.org/10.3892/or.17.5.1061
Copy and paste a formatted citation
x
Spandidos Publications style
Saito N, Kameoka S and Furukawa R: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncol Rep 17: 1061-1065, 2007.
APA
Saito, N., Kameoka, S., & Furukawa, R. (2007). Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. Oncology Reports, 17, 1061-1065. https://doi.org/10.3892/or.17.5.1061
MLA
Saito, N., Kameoka, S., Furukawa, R."Gene profile analysis of colorectal cancer cell lines by cDNA macroarray". Oncology Reports 17.5 (2007): 1061-1065.
Chicago
Saito, N., Kameoka, S., Furukawa, R."Gene profile analysis of colorectal cancer cell lines by cDNA macroarray". Oncology Reports 17, no. 5 (2007): 1061-1065. https://doi.org/10.3892/or.17.5.1061
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