The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis

  • Authors:
    • Jun-ichi Okano
    • Takakazu Nagahara
    • Kazuya Matsumoto
    • Yoshikazu Murawaki
  • View Affiliations

  • Published online on: May 1, 2007     https://doi.org/10.3892/or.17.5.1195
  • Pages: 1195-1200
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Abstract

Paclitaxel is a chemotherapeutic drug applied for the treatment of breast and non-small cell lung cancers. However, the biological effects of paclitaxel on hepatocellular carcinoma (HCC) are undefined. We examined these points by using the human HCC cell lines, and found that paclitaxel inhibited the growth of HCC cells and blocked the cell cycle at the G2/M phase. The cell death was partially mediated by apoptosis, because caspases were weakly activated and the cell death was partially rescued by a pan-caspase inhibitor. Paclitaxel activated extracellular signal-regulated kinase (ERK), and when ERK was inhibited by a mitogen-activated ERK-regulating kinase inhibitor, the cell death and cell cycle arrest induced by paclitaxel were rescued, demonstrating that paclitaxel inhibited the cellular growth via the ERK signaling pathway. Our data are promising for the application of paclitaxel in the treatment of patients with HCC.

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May 2007
Volume 17 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Okano J, Nagahara T, Matsumoto K and Murawaki Y: The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis. Oncol Rep 17: 1195-1200, 2007
APA
Okano, J., Nagahara, T., Matsumoto, K., & Murawaki, Y. (2007). The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis. Oncology Reports, 17, 1195-1200. https://doi.org/10.3892/or.17.5.1195
MLA
Okano, J., Nagahara, T., Matsumoto, K., Murawaki, Y."The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis". Oncology Reports 17.5 (2007): 1195-1200.
Chicago
Okano, J., Nagahara, T., Matsumoto, K., Murawaki, Y."The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis". Oncology Reports 17, no. 5 (2007): 1195-1200. https://doi.org/10.3892/or.17.5.1195