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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 18 Issue 1

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Article

Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing

  • Authors:
    • Inn-Wen Chong
    • Mei-Yin Chang
    • Chau-Chyun Sheu
    • Cheng-Yuan Wang
    • Jhi-Jhu Hwang
    • Ming-Shyan Huang
    • Shiu-Ru Lin

  • View Affiliations / Copyright

    Affiliations: Division of Pulmonary and Critical Care Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C.
  • Pages: 17-24
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.17
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Abstract

The ability to detect K-ras oncogene may provide additional information for the management of patients with non-small cell lung cancer (NSCLC). In the present study, we detected the K-ras oncogene in 76 patients with NSCLC by two methods: direct sequencing of K-ras in tumor tissues and membrane array detection of the gene overexpression specific for activated K-ras in peripheral blood. The results showed that 28 (36.8%) of the 76 Taiwanese NSCLC patients had K-ras mutations, with a frequency of 36.4% (20/55) in adenocarcinomas and 38.1% (8/21) in squamous cell carcinomas. The K-ras mutations were more frequently found in smokers than in non-smokers (51.4 vs. 24.4%, P=0.015). The incidences of K-ras mutation in the subgroups of non-smokers and squamous cell carcinomas are relatively higher in Taiwan than in other countries. On the other hand, the membrane array method could positively detect circulating activated K-ras in all of the 27 NSCLC patients with K-ras mutations at codons 12, 13 and 61, and in 4 of the 48 patients with wild-type K-ras. Our results suggest that the K-ras oncogene membrane array serves as a sensitive and convenient tool for the detection of K-ras oncogene, and therefore, has a great potential for clinical applications.

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Copy and paste a formatted citation
Spandidos Publications style
Chong I, Chang M, Sheu C, Wang C, Hwang J, Huang M and Lin S: Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing. Oncol Rep 18: 17-24, 2007.
APA
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., & Lin, S. (2007). Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing. Oncology Reports, 18, 17-24. https://doi.org/10.3892/or.18.1.17
MLA
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., Lin, S."Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing". Oncology Reports 18.1 (2007): 17-24.
Chicago
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., Lin, S."Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing". Oncology Reports 18, no. 1 (2007): 17-24. https://doi.org/10.3892/or.18.1.17
Copy and paste a formatted citation
x
Spandidos Publications style
Chong I, Chang M, Sheu C, Wang C, Hwang J, Huang M and Lin S: Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing. Oncol Rep 18: 17-24, 2007.
APA
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., & Lin, S. (2007). Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing. Oncology Reports, 18, 17-24. https://doi.org/10.3892/or.18.1.17
MLA
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., Lin, S."Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing". Oncology Reports 18.1 (2007): 17-24.
Chicago
Chong, I., Chang, M., Sheu, C., Wang, C., Hwang, J., Huang, M., Lin, S."Detection of activated K-ras in non-small cell lung cancer by membrane array: A comparison with direct sequencing". Oncology Reports 18, no. 1 (2007): 17-24. https://doi.org/10.3892/or.18.1.17
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