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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 18 Issue 1

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Article

CYP2A6 overexpression in human lung cancers correlates with a high malignant status

  • Authors:
    • Yoko Matsuda
    • Keiko Yamakawa
    • Kousuke Saoo
    • Kyoko Hosokawa
    • Masanao Yokohira
    • Toshiya Kuno
    • Junko Iwai
    • Takatoshi Shirai
    • Kaoru Obika
    • Tetsuya Kamataki
    • Katsumi Imaida

  • View Affiliations / Copyright

    Affiliations: Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa 761-0793, Japan
  • Pages: 53-57
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.53
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Abstract

CYP2A6 is a major phase I enzyme metabolizing tobacco-specific nitrosamines, implicated as risk factors for lung cancer. In this study, immunohistochemistry and in situ hybridization (ISH) for CYP2A6 with human lung cancer tissues (n=31) obtained by surgical resection showed significantly higher immunoreactivity in the cases with lymph node metastasis. The adenocarcinoma cases (n=23) with lymph node metastasis or large tumor size showed a high immunoreactivity for CYP2A6. The squamous cell carcinoma cases (n=6) with large tumor size showed a tendency for low CYP2A6 immunoreactivity. ISH for CYP2A6 revealed mRNA expression in both adenocarcinoma and squamous cell carcinoma cells. The data suggest that CYP2A6 could have an important role in the development and proliferation of lung carcinomas. With adenocarcinomas, CYP2A6 could be a target candidate for therapeutic and chemopreventive intervention.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Kamataki T, et al: CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncol Rep 18: 53-57, 2007.
APA
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T. ... Imaida, K. (2007). CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncology Reports, 18, 53-57. https://doi.org/10.3892/or.18.1.53
MLA
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T., Iwai, J., Shirai, T., Obika, K., Kamataki, T., Imaida, K."CYP2A6 overexpression in human lung cancers correlates with a high malignant status". Oncology Reports 18.1 (2007): 53-57.
Chicago
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T., Iwai, J., Shirai, T., Obika, K., Kamataki, T., Imaida, K."CYP2A6 overexpression in human lung cancers correlates with a high malignant status". Oncology Reports 18, no. 1 (2007): 53-57. https://doi.org/10.3892/or.18.1.53
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuda Y, Yamakawa K, Saoo K, Hosokawa K, Yokohira M, Kuno T, Iwai J, Shirai T, Obika K, Kamataki T, Kamataki T, et al: CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncol Rep 18: 53-57, 2007.
APA
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T. ... Imaida, K. (2007). CYP2A6 overexpression in human lung cancers correlates with a high malignant status. Oncology Reports, 18, 53-57. https://doi.org/10.3892/or.18.1.53
MLA
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T., Iwai, J., Shirai, T., Obika, K., Kamataki, T., Imaida, K."CYP2A6 overexpression in human lung cancers correlates with a high malignant status". Oncology Reports 18.1 (2007): 53-57.
Chicago
Matsuda, Y., Yamakawa, K., Saoo, K., Hosokawa, K., Yokohira, M., Kuno, T., Iwai, J., Shirai, T., Obika, K., Kamataki, T., Imaida, K."CYP2A6 overexpression in human lung cancers correlates with a high malignant status". Oncology Reports 18, no. 1 (2007): 53-57. https://doi.org/10.3892/or.18.1.53
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