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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2007 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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Article

Up-regulated claudin 7 expression in intestinal-type gastric carcinoma

  • Authors:
    • Jeong Youp Park
    • Kyung Hwa Park
    • Tae Yun Oh
    • Sung Pil Hong
    • Tae Joo Jeon
    • Chang Hoon Kim
    • Seung Woo Park
    • Jae Bock Chung
    • Si Young Song
    • Seungmin Bang

  • View Affiliations / Copyright

    Affiliations: Division of Gastroenterology, Department of Internal Medicine, Yonsei Institute of Gastroenterology, Yonsei University College of Medicine, 120-752 Seoul, Korea
  • Pages: 377-382
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/or.18.2.377
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Abstract

The disruption of tight junction protein expression in cancer might account for invasiveness, loss of cohesion, and lack of differentiation. Our cDNA array data indicated that claudin 7 was up-regulated in gastric carcinoma. We investigated the expression patterns and clinical implications of claudin 7 in gastric cancer. By immunohistochemical staining and Western blot, claudin 7 was significantly more often expressed in intestinal metaplasia, adenoma and cancer than in normal gastric epithelium. Twenty-seven (47.4%) of 57 normal gastric epithelium samples did not express claudin 7, but 50 (86.2%) of 58 intestinal metaplasia, 11 (91.7%) of 12 adenoma tissues, and 129 (82.7%) of 156 cancer samples did. Claudin 7 was more often unexpressed in diffuse type gastric cancer than in intestinal type. Only 13 (11.2%) of 116 intestinal type samples did not express claudin 7, but 14 (41.2%) of 34 diffuse type samples showed no expression. Compared to normal gastric epithelium, intestinal type gastric cancer significantly more often expressed claudin 7, but diffuse type did not. The expression pattern of claudin 7 did not change as cancer progressed. In this study we show that claudin 7 expression changed with the gastric carcinogenic process and that this is implicated in cancer characteristics.

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Copy and paste a formatted citation
Spandidos Publications style
Park JY, Park KH, Oh TY, Hong SP, Jeon TJ, Kim CH, Park SW, Chung JB, Song SY, Bang S, Bang S, et al: Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. Oncol Rep 18: 377-382, 2007.
APA
Park, J.Y., Park, K.H., Oh, T.Y., Hong, S.P., Jeon, T.J., Kim, C.H. ... Bang, S. (2007). Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. Oncology Reports, 18, 377-382. https://doi.org/10.3892/or.18.2.377
MLA
Park, J. Y., Park, K. H., Oh, T. Y., Hong, S. P., Jeon, T. J., Kim, C. H., Park, S. W., Chung, J. B., Song, S. Y., Bang, S."Up-regulated claudin 7 expression in intestinal-type gastric carcinoma". Oncology Reports 18.2 (2007): 377-382.
Chicago
Park, J. Y., Park, K. H., Oh, T. Y., Hong, S. P., Jeon, T. J., Kim, C. H., Park, S. W., Chung, J. B., Song, S. Y., Bang, S."Up-regulated claudin 7 expression in intestinal-type gastric carcinoma". Oncology Reports 18, no. 2 (2007): 377-382. https://doi.org/10.3892/or.18.2.377
Copy and paste a formatted citation
x
Spandidos Publications style
Park JY, Park KH, Oh TY, Hong SP, Jeon TJ, Kim CH, Park SW, Chung JB, Song SY, Bang S, Bang S, et al: Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. Oncol Rep 18: 377-382, 2007.
APA
Park, J.Y., Park, K.H., Oh, T.Y., Hong, S.P., Jeon, T.J., Kim, C.H. ... Bang, S. (2007). Up-regulated claudin 7 expression in intestinal-type gastric carcinoma. Oncology Reports, 18, 377-382. https://doi.org/10.3892/or.18.2.377
MLA
Park, J. Y., Park, K. H., Oh, T. Y., Hong, S. P., Jeon, T. J., Kim, C. H., Park, S. W., Chung, J. B., Song, S. Y., Bang, S."Up-regulated claudin 7 expression in intestinal-type gastric carcinoma". Oncology Reports 18.2 (2007): 377-382.
Chicago
Park, J. Y., Park, K. H., Oh, T. Y., Hong, S. P., Jeon, T. J., Kim, C. H., Park, S. W., Chung, J. B., Song, S. Y., Bang, S."Up-regulated claudin 7 expression in intestinal-type gastric carcinoma". Oncology Reports 18, no. 2 (2007): 377-382. https://doi.org/10.3892/or.18.2.377
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