Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer

  • Authors:
    • M. A. González-Moles
    • J. A. Gil-Montoya
    • I. Ruiz-Avila
    • F. Esteban
    • M. Delgado-Rodriguez
    • A. Bascones-Martinez
  • View Affiliations

  • Published online on: August 1, 2007     https://doi.org/10.3892/or.18.2.389
  • Pages: 389-396
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Abstract

The role of lost or reduced expression of p21, p16 and CD44s in the survival of tongue cancer patients was investigated. Tumours and adjacent non-tumour epithelia (ANTE) from 36 patients with tongue cancer were retrospectively studied by immunohistochemistry using monoclonal antibodies against p21, p16 and CD44s proteins. Expression of p21, p16 and CD44s and their relationship with clinical and pathological parameters were analyzed. Of 36 patients, 12 (33.33%) developed recurrence and 12 died of the disease (mean survival, 25.5 months). In four cases (11.1%), concomitant low expression (<50% of tumour cells) of p21, p16 and CD44s was detected but had no effect on survival or recurrence in the univariate analysis. In the multivariate analysis, low expression of CD44s was the sole prognostic factor related to survival (p=0.01, hazards ratio: 0.749). There was no expression of p21, p16 or CD44s in ANTE from 3 out of 24 cases studied, and this finding was related to recurrence in the univariate analysis. In the multivariate analysis, low expression of CD44s in ANTE was again the sole factor related to recurrence (p=0.002, hazards ratio: 0.028). In conclusion, low expression of CD44s is related to tumour cell invasiveness and may be of clinical relevance as a prognostic factor.

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August 2007
Volume 18 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
González-Moles MA, Gil-Montoya JA, Ruiz-Avila I, Esteban F, Delgado-Rodriguez M and Bascones-Martinez A: Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer. Oncol Rep 18: 389-396, 2007.
APA
González-Moles, M.A., Gil-Montoya, J.A., Ruiz-Avila, I., Esteban, F., Delgado-Rodriguez, M., & Bascones-Martinez, A. (2007). Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer. Oncology Reports, 18, 389-396. https://doi.org/10.3892/or.18.2.389
MLA
González-Moles, M. A., Gil-Montoya, J. A., Ruiz-Avila, I., Esteban, F., Delgado-Rodriguez, M., Bascones-Martinez, A."Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer". Oncology Reports 18.2 (2007): 389-396.
Chicago
González-Moles, M. A., Gil-Montoya, J. A., Ruiz-Avila, I., Esteban, F., Delgado-Rodriguez, M., Bascones-Martinez, A."Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer". Oncology Reports 18, no. 2 (2007): 389-396. https://doi.org/10.3892/or.18.2.389