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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2007 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions

  • Authors:
    • Angelina Di Carlo
    • Angela Mariano
    • Daniela Terracciano
    • Claudia Mazzarella
    • Sonia Galzerano
    • Marcellino Cicalese
    • Ciriaco Cecere
    • Vincenzo Macchia

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Medicina Sperimentale, Università di Roma ‘La Sapienza’, I-00161 Roma, Italy
  • Pages: 425-431
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/or.18.2.425
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Abstract

Matrix metalloproteinases (MMPs) are proteolytic enzymes that are implicated in multiple stages of cancer progression including invasion and metastasis. MMPs exert these effects by cleaving a diverse group of substrates, which include not only structural components of the extracellular matrix, but also growth factor receptors. By gelatin zymography we verified MMP activity in the pleural effusions of patients with benign and malignant disease. Of these patients, 32 had malignant pleural effusion, consisting of 20 breast cancer, 6 non-small cell lung carcinoma, 4 ovarian carcinoma, and 2 colonic adenocarcinoma, and 10 had benign pleural effusion (5 pleurisy and 5 cirrhosis). Zymography showed the constant presence of a substantial amount of MMP-2 in all samples analyzed, whereas MMP-9 was present to lesser quantities. MMP-2 activity was enhanced in pleural effusions from patients with benign diseases compared with cancer patients. MMP-9 was present in 59% of cancer patients and the lytic activity was enhanced in pleurisy and absent in cirrhosis. Furthermore, we determined the pleural effusion levels of the soluble extracellular domain of HER-2/neu. The levels of HER-2/neu ECD were above the cut-off value in breast cancer patients. No correlation between gelatinolytic activities and high HER-2/neu ECD values was found.

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Copy and paste a formatted citation
Spandidos Publications style
Di Carlo A, Mariano A, Terracciano D, Mazzarella C, Galzerano S, Cicalese M, Cecere C and Macchia V: Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Oncol Rep 18: 425-431, 2007.
APA
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M. ... Macchia, V. (2007). Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Oncology Reports, 18, 425-431. https://doi.org/10.3892/or.18.2.425
MLA
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M., Cecere, C., Macchia, V."Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions". Oncology Reports 18.2 (2007): 425-431.
Chicago
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M., Cecere, C., Macchia, V."Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions". Oncology Reports 18, no. 2 (2007): 425-431. https://doi.org/10.3892/or.18.2.425
Copy and paste a formatted citation
x
Spandidos Publications style
Di Carlo A, Mariano A, Terracciano D, Mazzarella C, Galzerano S, Cicalese M, Cecere C and Macchia V: Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Oncol Rep 18: 425-431, 2007.
APA
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M. ... Macchia, V. (2007). Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions. Oncology Reports, 18, 425-431. https://doi.org/10.3892/or.18.2.425
MLA
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M., Cecere, C., Macchia, V."Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions". Oncology Reports 18.2 (2007): 425-431.
Chicago
Di Carlo, A., Mariano, A., Terracciano, D., Mazzarella, C., Galzerano, S., Cicalese, M., Cecere, C., Macchia, V."Gelatinolytic activities (matrix metalloproteinase-2 and -9) and soluble extracellular domain of Her-2/neu in pleural effusions". Oncology Reports 18, no. 2 (2007): 425-431. https://doi.org/10.3892/or.18.2.425
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