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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2007 Volume 18 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine

  • Authors:
    • Akihiro Hirata
    • Tetsuya Tsukamoto
    • Masami Yamamoto
    • Shinji Takasu
    • Hiroki Sakai
    • Hisayo Ban
    • Tokuma Yanai
    • Toshiaki Masegi
    • Lawrence A. Donehower
    • Masae Tatematsu

  • View Affiliations / Copyright

    Affiliations: Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan
  • Pages: 755-761
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/or.18.4.755
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Abstract

p53 knockout mice have been utilized for the functional analysis of p53 in carcinogenic processes and for the evaluation of the carcinogenic potential of chemicals. In this study, we established that p53 knockout mice have an elevated susceptibility to the induction of histiocytic sarcoma (HS) by N-bis(2-hydroxy-propyl)nitrosamine (BHP). p53 heterozygous (+/−) and wild-type (+/+) mice were treated with 20 or 200 ppm BHP in their drinking water for 15 weeks or with 20 ppm BHP for 40 weeks. An additional group of p53 nullizygous (−/−) mice were treated with 20 ppm BHP for 15 weeks. In a 15-week experiment, hepatic HSs were unexpectedly observed in BHP-treated p53 (−/−) mice (30.8%) but not in p53 (+/−) and (+/+) mice and untreated (−/−) mice, indicating that a complete loss of p53 dramatically accelerates the genesis of HS. In a 40-week experiment, HSs were significantly increased in female p53 (+/−) mice (37.5%) as compared with female (+/+) mice (5.0%). Additionally, PCR-SSCP and sequencing analysis revealed a high frequency of p53 gene mutations in HSs, demonstrating the involvement of p53 gene mutations in HS development. Our data add to the understanding of the carcinogenic susceptibility of p53 knockout mice, and may help to elucidate the pathogenesis of HS development.

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Copy and paste a formatted citation
Spandidos Publications style
Hirata A, Tsukamoto T, Yamamoto M, Takasu S, Sakai H, Ban H, Yanai T, Masegi T, Donehower LA, Tatematsu M, Tatematsu M, et al: Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncol Rep 18: 755-761, 2007.
APA
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H. ... Tatematsu, M. (2007). Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncology Reports, 18, 755-761. https://doi.org/10.3892/or.18.4.755
MLA
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H., Yanai, T., Masegi, T., Donehower, L. A., Tatematsu, M."Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine". Oncology Reports 18.4 (2007): 755-761.
Chicago
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H., Yanai, T., Masegi, T., Donehower, L. A., Tatematsu, M."Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine". Oncology Reports 18, no. 4 (2007): 755-761. https://doi.org/10.3892/or.18.4.755
Copy and paste a formatted citation
x
Spandidos Publications style
Hirata A, Tsukamoto T, Yamamoto M, Takasu S, Sakai H, Ban H, Yanai T, Masegi T, Donehower LA, Tatematsu M, Tatematsu M, et al: Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncol Rep 18: 755-761, 2007.
APA
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H. ... Tatematsu, M. (2007). Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncology Reports, 18, 755-761. https://doi.org/10.3892/or.18.4.755
MLA
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H., Yanai, T., Masegi, T., Donehower, L. A., Tatematsu, M."Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine". Oncology Reports 18.4 (2007): 755-761.
Chicago
Hirata, A., Tsukamoto, T., Yamamoto, M., Takasu, S., Sakai, H., Ban, H., Yanai, T., Masegi, T., Donehower, L. A., Tatematsu, M."Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine". Oncology Reports 18, no. 4 (2007): 755-761. https://doi.org/10.3892/or.18.4.755
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