Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients

  • Authors:
    • Isamu Hoshino
    • Hisahiro Matsubara
    • Yasunori Akutsu
    • Takanori Nishimori
    • Yasuo Yoneyama
    • Kentaro Murakami
    • Haruhito Sakata
    • Kazuyuki Matsushita
    • Takenori Ochiai
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/or.18.4.867
  • Pages: 867-871
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Abstract

Peroxiredoxins (Prdxs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. Some reports have shown that the overexpression of Prdx1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. In this study, we investigated the expression levels of Prdx1 in esophageal squamous cell carcinoma by immunohistochemistry, and the correlation between the Prdx1 expression and the clinical status was elucidated. Immunohistochemical staining was performed in 114 samples which were collected from surgical esophageal cancer specimens. Cytoplasmic staining of Prdx1 was evaluated based on the following scoring criteria: Grade I, negative or weak staining; Grade II, moderate staining; and Grade III, strong staining. The percentage of patients with a Grade I expression of Prx1 was 20% (23 of 114), 44% had Grade II (50 of 114), and 36% had Grade III (41 of 114). The Prdx1 immunoreactivity showed an inverse significant correlation with T-category (P<0.0001), lymph node metastasis (P=0.048), and stage (P=0.001). In addition, the patients with tumors exhibiting a reduced Prdx1 expression had shorter overall survival (P=0.022) in comparison to the patients with tumors which had a higher Prdx1 expression. Currently, Prdx1 has been shown to act as a tumor suppressor. Our results provide strong evidence that the reduced Prdx1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

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October 2007
Volume 18 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hoshino I, Matsubara H, Akutsu Y, Nishimori T, Yoneyama Y, Murakami K, Sakata H, Matsushita K and Ochiai T: Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients. Oncol Rep 18: 867-871, 2007
APA
Hoshino, I., Matsubara, H., Akutsu, Y., Nishimori, T., Yoneyama, Y., Murakami, K. ... Ochiai, T. (2007). Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients. Oncology Reports, 18, 867-871. https://doi.org/10.3892/or.18.4.867
MLA
Hoshino, I., Matsubara, H., Akutsu, Y., Nishimori, T., Yoneyama, Y., Murakami, K., Sakata, H., Matsushita, K., Ochiai, T."Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients". Oncology Reports 18.4 (2007): 867-871.
Chicago
Hoshino, I., Matsubara, H., Akutsu, Y., Nishimori, T., Yoneyama, Y., Murakami, K., Sakata, H., Matsushita, K., Ochiai, T."Tumor suppressor Prdx1 is a prognostic factor in esophageal squamous cell carcinoma patients". Oncology Reports 18, no. 4 (2007): 867-871. https://doi.org/10.3892/or.18.4.867