Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation

  • Authors:
    • Eun-Young Ahn
    • Yahong Jiang
    • Yanjun Zhang
    • Eun Mi Son
    • Song You
    • Shin-Won Kang
    • Jang-Su Park
    • Jee H. Jung
    • Burm-Jong Lee
    • Dong-Kyoo Kim
  • View Affiliations

  • Published online on: February 1, 2008     https://doi.org/10.3892/or.19.2.527
  • Pages: 527-534
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Abstract

p-Tyrosol is a phenolic compound present in different dietary sources that can exert mild antioxidant properties based on in vitro and in vivo studies. In our study, two p-tyrosol derivatives (p-tyrosyl gallate and p-tyrosyl acetate) were synthesized and compared together with p-tyrosol and gallic acid for their cytotoxic activities on human cancer cells. p-Tyrosyl gallate had the most potent cytotoxicity and the major cytotoxic mechanism of its action was studied. We found that in HeLa cells, p-tyrosyl gallate can effectively induce cell cycle arrest during S phase and inhibited in vitro simian virus (SV40 DNA) replication. In addition, p-tyrosyl gallate can inhibit three important functional replication proteins (topoisomerase I, RPA and pol α-primase), especially pol α-primase. These results suggest that p-tyrosyl gallate-induced cell cycle arrest during S phase correlates with the inhibition of DNA replication. Pol α-primase may be the main target molecule. Taken together, we suggest that p-tyrosyl gallate is a strong anticancer drug candidate that warrants further investigation.

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February 2008
Volume 19 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Ahn E, Jiang Y, Zhang Y, Son EM, You S, Kang S, Park J, Jung JH, Lee B, Kim D, Kim D, et al: Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation. Oncol Rep 19: 527-534, 2008
APA
Ahn, E., Jiang, Y., Zhang, Y., Son, E.M., You, S., Kang, S. ... Kim, D. (2008). Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation. Oncology Reports, 19, 527-534. https://doi.org/10.3892/or.19.2.527
MLA
Ahn, E., Jiang, Y., Zhang, Y., Son, E. M., You, S., Kang, S., Park, J., Jung, J. H., Lee, B., Kim, D."Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation". Oncology Reports 19.2 (2008): 527-534.
Chicago
Ahn, E., Jiang, Y., Zhang, Y., Son, E. M., You, S., Kang, S., Park, J., Jung, J. H., Lee, B., Kim, D."Cytotoxicity of p-tyrosol and its derivatives may correlate with the inhibition of DNA replication initiation". Oncology Reports 19, no. 2 (2008): 527-534. https://doi.org/10.3892/or.19.2.527